M
Marcel A. T. M. van Vugt
Researcher at University Medical Center Groningen
Publications - 100
Citations - 6058
Marcel A. T. M. van Vugt is an academic researcher from University Medical Center Groningen. The author has contributed to research in topics: DNA repair & Cell cycle. The author has an hindex of 34, co-authored 88 publications receiving 4927 citations. Previous affiliations of Marcel A. T. M. van Vugt include Utrecht University & University Medical Center Utrecht.
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Journal ArticleDOI
Systematic Discovery of In Vivo Phosphorylation Networks
Rune Linding,Rune Linding,Lars Juhl Jensen,Gerard J. Ostheimer,Marcel A. T. M. van Vugt,Marcel A. T. M. van Vugt,Claus Jørgensen,Ioana M. Miron,Francesca Diella,Karen Colwill,Lorne Taylor,Kelly Elder,Pavel Metalnikov,Vivian Nguyen,Adrian Pasculescu,Jing Jin,Jin Park,Leona D. Samson,James R. Woodgett,Robert B. Russell,Peer Bork,Michael B. Yaffe,Tony Pawson +22 more
TL;DR: An approach is developed that augments motif-based predictions with the network context of kinases and phosphoproteins, which suggests that BCLAF1 is a GSK-3 substrate and yields a 2.5-fold improvement in the accuracy with which phosphorylation networks can be constructed.
Journal ArticleDOI
Polo-like Kinase-1 Controls Recovery from a G2 DNA Damage-Induced Arrest in Mammalian Cells
TL;DR: The data show that the cell cycle machinery is reset in response to DNA damage and that cells become critically dependent on Plk1-mediated degradation of Wee1 for their recovery.
Journal ArticleDOI
Gene expression analysis identifies global gene dosage sensitivity in cancer
Rudolf S N Fehrmann,Juha Karjalainen,Małgorzata Krajewska,Harm-Jan Westra,David J. Maloney,Anton Simeonov,Tune H. Pers,Joel N. Hirschhorn,Ritsert C. Jansen,Erik Anthony Schultes,Herman H. H. B. M. Van Haagenl,Elisabeth G.E. de Vries,Gerard J. te Meerman,Cisca Wijmenga,Marcel A. T. M. van Vugt,Lude Franke +15 more
TL;DR: This work reanalyzed expression profiles and observed a limited set of 'transcriptional components' that describe well-known biology, explain the vast majority of variation in gene expression and enable us to predict the biological function of genes.
Journal ArticleDOI
Getting in and out of mitosis with Polo-like kinase-1.
TL;DR: Polo-like kinase-1 appears to play a role at multiple points during a restart of the cell cycle following DNA damage, and possible consequences of using Plk1 as a target in anticancer strategies are discussed.
Journal ArticleDOI
Relevance of Tumor-Infiltrating Immune Cell Composition and Functionality for Disease Outcome in Breast Cancer.
Rico D. Bense,Christos Sotiriou,Martine Piccart-Gebhart,John B. A. G. Haanen,Marcel A. T. M. van Vugt,Elisabeth Ge E Liesbeth E. de Vries,Carolien P. Schröder,Rudolf Rs Fehrmann +7 more
TL;DR: The main hypothesis generated in this unbiased in silico approach is that a multitude of immune cells are related to treatment response and outcome in breast cancer.