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Sheu Ran Choi

Researcher at Seoul National University

Publications -  27
Citations -  631

Sheu Ran Choi is an academic researcher from Seoul National University. The author has contributed to research in topics: Neuropathic pain & Astrocyte. The author has an hindex of 14, co-authored 27 publications receiving 522 citations.

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Journal ArticleDOI

Spinal neuronal NOS activation mediates sigma-1 receptor-induced mechanical and thermal hypersensitivity in mice: involvement of PKC-dependent GluN1 phosphorylation

Dae Hyun Roh, +8 more
- 01 Aug 2011 - 
TL;DR: The role of NO is examined in this process, as it plays a critical role in PKC‐mediated calcium signalling and the potentiation of NMDA receptor function.
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σ1 receptors activate astrocytes via p38 MAPK phosphorylation leading to the development of mechanical allodynia in a mouse model of neuropathic pain.

Jiyoung Moon, +10 more
- 01 Dec 2014 - 
TL;DR: It is demonstrated that the spinal sigma non‐opioid intracellular receptor 1 (σ1 receptor) modulates p38 MAPK phosphorylation (p‐p38), which plays a critical role in the induction of MA in neuropathic rats.
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Spinal sigma-1 receptors activate NADPH oxidase 2 leading to the induction of pain hypersensitivity in mice and mechanical allodynia in neuropathic rats.

Sheu Ran Choi, +10 more
- 01 Aug 2013 - 
TL;DR: It is demonstrated that spinal Sig-1Rs modulate Nox2 activation and ROS production in the spinal cord, and ultimately contribute to the Sig- 1R-induced pain hypersensitivity and the peripheral nerve injury-induced induction of chronic neuropathic pain.
Journal ArticleDOI

Microglial interleukin-1β in the ipsilateral dorsal horn inhibits the development of mirror-image contralateral mechanical allodynia through astrocyte activation in a rat model of inflammatory pain.

Hoon Seong Choi, +11 more
- 01 Jan 2015 - 
TL;DR: Results suggest that spinal IL-1&bgr; derived from activated microglia temporarily suppresses astrocyte activation, which can ultimately prevent the development of contralateral MA under inflammatory conditions, and imply that microglial IL- 1&b gr; plays an important role in regulating the induction of inflammatory MIP.
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Blockade of peripheral P2Y1 receptors prevents the induction of thermal hyperalgesia via modulation of TRPV1 expression in carrageenan-induced inflammatory pain rats: Involvement of p38 MAPK phosphorylation in DRGs

Soon Gu Kwon, +9 more
- 01 Apr 2014 - 
TL;DR: Data demonstrate a sequential role for P2Y1R, p38 MAPK and TRPV1 in inflammation-induced thermal hyperalgesia; thus, peripheral P2y1Rs activation modulates p38MAPK signaling and TRpV1 expression, which ultimately leads to the induction of thermal hyperAlgesia.