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Journal ArticleDOI

Spinal sigma-1 receptors activate NADPH oxidase 2 leading to the induction of pain hypersensitivity in mice and mechanical allodynia in neuropathic rats.

Sheu Ran Choi, +10 more
- 01 Aug 2013 - 
- Vol. 74, pp 56-67
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TLDR
It is demonstrated that spinal Sig-1Rs modulate Nox2 activation and ROS production in the spinal cord, and ultimately contribute to the Sig- 1R-induced pain hypersensitivity and the peripheral nerve injury-induced induction of chronic neuropathic pain.
About: 
This article is published in Pharmacological Research.The article was published on 2013-08-01. It has received 49 citations till now. The article focuses on the topics: Neuropathic pain & Apocynin.

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Citations
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Journal ArticleDOI

The Sigma-1 Receptor as a Pluripotent Modulator in Living Systems

Tsung-Ping Su, +3 more
- 01 Apr 2016 - 
TL;DR: This work proposes that Sig-1R is a pluripotent modulator with resultant multiple functional manifestations in living systems and investigates its role in central nervous system diseases.
Journal ArticleDOI

New insights on NOX enzymes in the central nervous system.

Zeynab Nayernia, +2 more
- 10 Jun 2014 - 
TL;DR: Physiological and pathophysiological studies with cell-type-specific knock-out mice will be necessary to delineate the precise functions of NOX enzymes and their implications in pathomechanisms, and the development of CNS-permeant, specific NOX inhibitors will be needed to advance toward therapeutic applications.
Journal ArticleDOI

Curcumin ameliorated diabetic neuropathy partially by inhibition of NADPH oxidase mediating oxidative stress in the spinal cord

Wei-cheng Zhao, +6 more
- 07 Feb 2014 - 
TL;DR: In conclusion, curcumin attenuated neuropathic pain in diabetic rats, at least partly by inhibiting NADPH oxidase-mediating oxidative stress in the spinal cord.
Journal ArticleDOI

Loss of phenotype of parvalbumin interneurons in rat prefrontal cortex is involved in antidepressant- and propsychotic-like behaviors following acute and repeated ketamine administration.

Zhi-Qiang Zhou, +8 more
- 01 Apr 2015 - 
TL;DR: The results reveal that the loss of phenotype of PV interneurons in the prefrontal cortex contributes to the antidepressant-like actions and is also involved in the propsychotic-like behaviors following acute and repeated ketamine administration, which may be partially mediated by the disinhibition of glutamate signaling.
Journal ArticleDOI

Investigational sigma-1 receptor antagonists for the treatment of pain.

José Miguel Vela, +2 more
- 22 Jun 2015 - 
TL;DR: Current preclinical evidence provides strong rationale for σ1R antagonists in pain, and the outcome of clinical studies with the most advanced investigational ρ1R antagonist, S1RA (E-52862), will be of great interest to ascertain the potential of this new therapeutic approach to pain management.
References
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Journal ArticleDOI

The NOX Family of ROS-Generating NADPH Oxidases: Physiology and Pathophysiology

Karen Bedard, +1 more
- 01 Jan 2007 - 
TL;DR: This review summarizes the current state of knowledge of the functions of NOX enzymes in physiology and pathology.
Journal ArticleDOI

A peripheral mononeuropathy in rat that produces disorders of pain sensation like those seen in man.

Gary J. Bennett, +1 more
- 01 Apr 1988 - 
TL;DR: A peripheral mononeuropathy was produced in adult rats by placing loosely constrictive ligatures around the common sciatic nerve and the postoperative behavior of these rats indicated that hyperalgesia, allodynia and, possibly, spontaneous pain were produced.
Journal ArticleDOI

A new and sensitive method for measuring thermal nociception in cutaneous hyperalgesia.

Kenneth M. Hargreaves, +4 more
- 01 Jan 1988 - 
TL;DR: Both the thermal method and the Randall‐Selitto mechanical method detected dose‐related hyperalgesia and its blockade by either morphine or indomethacin, but the Thermal method showed greater bioassay sensitivity and allowed for the measurement of other behavioral parameters in addition to the nociceptive threshold.
Journal Article

A new and sensitive method for measuring thermal nociception in cutaneous hyperalgesia.

Mark J F Brown, +4 more
- 30 Dec 1987 - 
Journal ArticleDOI

NOX enzymes and the biology of reactive oxygen

J. David Lambeth
- 01 Mar 2004 - 
TL;DR: Professional phagocytes generate high levels of reactive oxygen species (ROS) using a superoxide-generating NADPH oxidase as part of their armoury of microbicidal mechanisms, leading to the concept that ROS are 'intentionally' generated in these cells with distinctive cellular functions related to innate immunity, signal transduction and modification of the extracellular matrix.
Related Papers (5)

Sigma-1 Receptor Chaperones at the ER- Mitochondrion Interface Regulate Ca2+ Signaling and Cell Survival

Teruo Hayashi, +1 more
- 02 Nov 2007 - 

The sigma-1 receptor chaperone as an inter-organelle signaling modulator.

Tsung-Ping Su, +4 more
- 01 Dec 2010 - 

Intrathecal injection of the ς1 receptor antagonist BD1047 blocks both mechanical allodynia and increases in spinal NR1 expression during the induction phase of rodent neuropathic pain

Dae Hyun Roh, +9 more
- 01 Nov 2008 - 

Pharmacological properties of S1RA, a new sigma-1 receptor antagonist that inhibits neuropathic pain and activity-induced spinal sensitization.

Luz Romero, +23 more
- 01 Aug 2012 - 

Intrathecal morphine in mice: a new technique.

J. L.K. Hylden, +1 more
- 17 Oct 1980 -