σ1 receptors activate astrocytes via p38 MAPK phosphorylation leading to the development of mechanical allodynia in a mouse model of neuropathic pain.
Jiyoung Moon,Dae Hyun Roh,Seo Yeon Yoon,Sheu Ran Choi,Soon Gu Kwon,Hoon Seong Choi,S. Y. Kang,Ho Jae Han,Alvin J. Beitz,Seog Bae Oh,Jang Hern Lee +10 more
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TLDR
It is demonstrated that the spinal sigma non‐opioid intracellular receptor 1 (σ1 receptor) modulates p38 MAPK phosphorylation (p‐p38), which plays a critical role in the induction of MA in neuropathic rats.Abstract:
Background and Purpose
Spinal astrocytes have emerged as important mechanistic contributors to the genesis of mechanical allodynia (MA) in neuropathic pain. We recently demonstrated that the spinal sigma non-opioid intracellular receptor 1 (σ1 receptor) modulates p38 MAPK phosphorylation (p-p38), which plays a critical role in the induction of MA in neuropathic rats. However, the histological and physiological relationships among σ1, p-p38 and astrocyte activation is unclear.read more
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The Sigma-1 Receptor as a Pluripotent Modulator in Living Systems
TL;DR: This work proposes that Sig-1R is a pluripotent modulator with resultant multiple functional manifestations in living systems and investigates its role in central nervous system diseases.
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Aβ-Induced Drp1 phosphorylation through Akt activation promotes excessive mitochondrial fission leading to neuronal apoptosis
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BDNF promotes activation of astrocytes and microglia contributing to neuroinflammation and mechanical allodynia in cyclophosphamide-induced cystitis
Honglu Ding,Jialiang Chen,Minzhi Su,Zhijun Lin,Hailun Zhan,Fei Yang,Wenbiao Li,Juncong Xie,Yong Huang,Xian-Guo Liu,Bolong Liu,Xiangfu Zhou +11 more
TL;DR: In the CYP-induced cystitis model, BDNF promoted the activation of astrocytes and microglia to release TNF-α and IL-1β, aggravating neuroinflammation and leading to mechanical allodynia through BDNF-TrkB-p38/JNK signaling.
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The α7 nicotinic receptor dual allosteric agonist and positive allosteric modulator GAT107 reverses nociception in mouse models of inflammatory and neuropathic pain.
Deniz Bagdas,Deniz Bagdas,Jenny L. Wilkerson,Abhijit R. Kulkarni,Wisam Toma,Shakir D. AlSharari,Shakir D. AlSharari,Zulfiye Gul,Aron H. Lichtman,Roger L. Papke,Ganesh A. Thakur,M. Imad Damaj +11 more
TL;DR: Orthosteric agonists and positive allosteric modulators (PAMs) of the α7 nicotinic ACh receptor (nAChR) represent novel therapeutic approaches for pain modulation and compounds with dual function as allosterics agonist and PAMs, known as ago‐P AMs, add further regulation of receptor function.
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Sigma-1 Receptor-Modulated Neuroinflammation in Neurological Diseases.
TL;DR: This review article discusses the recent advances on the Sig-1R-modulating neuro inflammation in the pathophysiology and therapy of neurodegenerative disorders and focuses on the emerging role of Sig- 1Rs in regulating neuroinflammation.
References
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