S
Sheu Ran Choi
Researcher at Seoul National University
Publications - 27
Citations - 631
Sheu Ran Choi is an academic researcher from Seoul National University. The author has contributed to research in topics: Neuropathic pain & Astrocyte. The author has an hindex of 14, co-authored 27 publications receiving 522 citations.
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Journal ArticleDOI
Spinal neuronal NOS activation mediates sigma-1 receptor-induced mechanical and thermal hypersensitivity in mice: involvement of PKC-dependent GluN1 phosphorylation
Dae Hyun Roh,Sheu Ran Choi,Seo Yeon Yoon,Suk Yun Kang,Jiyoung Moon,Soon Gu Kwon,Ho Jae Han,Alvin J. Beitz,Jang Hern Lee +8 more
TL;DR: The role of NO is examined in this process, as it plays a critical role in PKC‐mediated calcium signalling and the potentiation of NMDA receptor function.
Journal ArticleDOI
σ1 receptors activate astrocytes via p38 MAPK phosphorylation leading to the development of mechanical allodynia in a mouse model of neuropathic pain.
Jiyoung Moon,Dae Hyun Roh,Seo Yeon Yoon,Sheu Ran Choi,Soon Gu Kwon,Hoon Seong Choi,S. Y. Kang,Ho Jae Han,Alvin J. Beitz,Seog Bae Oh,Jang Hern Lee +10 more
TL;DR: It is demonstrated that the spinal sigma non‐opioid intracellular receptor 1 (σ1 receptor) modulates p38 MAPK phosphorylation (p‐p38), which plays a critical role in the induction of MA in neuropathic rats.
Journal ArticleDOI
Spinal sigma-1 receptors activate NADPH oxidase 2 leading to the induction of pain hypersensitivity in mice and mechanical allodynia in neuropathic rats.
Sheu Ran Choi,Dae Hyun Roh,Seo Yeon Yoon,Suk Yun Kang,Jiyoung Moon,Soon Gu Kwon,Hoon Seong Choi,Ho Jae Han,Alvin J. Beitz,Seog Bae Oh,Jang Hern Lee +10 more
TL;DR: It is demonstrated that spinal Sig-1Rs modulate Nox2 activation and ROS production in the spinal cord, and ultimately contribute to the Sig- 1R-induced pain hypersensitivity and the peripheral nerve injury-induced induction of chronic neuropathic pain.
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Microglial interleukin-1β in the ipsilateral dorsal horn inhibits the development of mirror-image contralateral mechanical allodynia through astrocyte activation in a rat model of inflammatory pain.
Hoon Seong Choi,Dae Hyun Roh,Seo Yeon Yoon,Jiyoung Moon,Sheu Ran Choi,Soon Gu Kwon,Suk Yun Kang,Ho Jae Han,Hyun-Woo Kim,Alvin J. Beitz,Seog Bae Oh,Jang Hern Lee +11 more
TL;DR: Results suggest that spinal IL-1&bgr; derived from activated microglia temporarily suppresses astrocyte activation, which can ultimately prevent the development of contralateral MA under inflammatory conditions, and imply that microglial IL- 1&b gr; plays an important role in regulating the induction of inflammatory MIP.
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Blockade of peripheral P2Y1 receptors prevents the induction of thermal hyperalgesia via modulation of TRPV1 expression in carrageenan-induced inflammatory pain rats: Involvement of p38 MAPK phosphorylation in DRGs
Soon Gu Kwon,Dae Hyun Roh,Seo Yeon Yoon,Jiyoung Moon,Sheu Ran Choi,Hoon Seong Choi,Suk Yun Kang,Ho Jae Han,Alvin J. Beitz,Jang Hern Lee +9 more
TL;DR: Data demonstrate a sequential role for P2Y1R, p38 MAPK and TRPV1 in inflammation-induced thermal hyperalgesia; thus, peripheral P2y1Rs activation modulates p38MAPK signaling and TRpV1 expression, which ultimately leads to the induction of thermal hyperAlgesia.