G
Gabrielle Gendron-Lepage
Researcher at Université de Montréal
Publications - 52
Citations - 1173
Gabrielle Gendron-Lepage is an academic researcher from Université de Montréal. The author has contributed to research in topics: Medicine & Antibody. The author has an hindex of 11, co-authored 26 publications receiving 473 citations.
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Journal ArticleDOI
Cross-Sectional Evaluation of Humoral Responses against SARS-CoV-2 Spike.
Jérémie Prévost,Romain Gasser,Guillaume Beaudoin-Bussières,Jonathan Richard,Ralf Duerr,Annemarie Laumaea,Sai Priya Anand,Guillaume Goyette,Mehdi Benlarbi,Shilei Ding,Halima Medjahed,Antoine Lewin,Josée Perreault,Tony Tremblay,Gabrielle Gendron-Lepage,Nicolas Gauthier,Marc Carrier,Diane Marcoux,Alain Piché,Myriam Lavoie,Alexandre Benoit,Vilayvong Loungnarath,Gino Brochu,Elie Haddad,Hannah D. Stacey,Matthew S. Miller,Marc Desforges,Pierre J. Talbot,Graham T. Gould Maule,Marceline Côté,Christian Therrien,Bouchra Serhir,Renée Bazin,Michel Roger,Andrés Finzi,Andrés Finzi +35 more
TL;DR: While most of individuals develop neutralizing antibodies within two weeks of infection, the level ofneutralizing activity is significantly decreased over time, highlighting the importance of studying the persistence of neutralizing activity upon natural SARS-CoV-2 infection.
Journal ArticleDOI
A single dose of the SARS-CoV-2 vaccine BNT162b2 elicits Fc-mediated antibody effector functions and T cell responses.
Alexandra Tauzin,Manon Nayrac,Mehdi Benlarbi,Shang Yu Gong,Romain Gasser,Guillaume Beaudoin-Bussières,Nathalie Brassard,Annemarie Laumaea,Dani Vézina,Jérémie Prévost,Sai Priya Anand,Catherine Bourassa,Gabrielle Gendron-Lepage,Halima Medjahed,Guillaume Goyette,Julia Niessl,Olivier Tastet,Laurie Gokool,Chantal Morrisseau,Pascale Arlotto,Leonidas Stamatatos,Leonidas Stamatatos,Andrew T. McGuire,Catherine Larochelle,Pradeep D. Uchil,Maolin Lu,Walther Mothes,Gaston De Serres,Sandrine Moreira,Michel Roger,Jonathan Richard,Valérie Martel-Laferrière,Ralf Duerr,Cécile Tremblay,Daniel Kaufmann,Andrés Finzi,Andrés Finzi +36 more
TL;DR: In this article, a single dose of the BNT162b2 mRNA vaccine for SARS-CoV-2 was found to be up to 90% effective starting 14 days post-administration.
Journal ArticleDOI
Longitudinal analysis of humoral immunity against SARS-CoV-2 Spike in convalescent individuals up to 8 months post-symptom onset.
Sai Priya Anand,Jérémie Prévost,Manon Nayrac,Guillaume Beaudoin-Bussières,Mehdi Benlarbi,Romain Gasser,Nathalie Brassard,Annemarie Laumaea,Shang Yu Gong,Catherine Bourassa,Elsa Brunet-Ratnasingham,Halima Medjahed,Gabrielle Gendron-Lepage,Guillaume Goyette,Laurie Gokool,Chantal Morrisseau,Philippe Bégin,Valérie Martel-Laferrière,Cécile Tremblay,Jonathan Richard,Renée Bazin,Ralf Duerr,Daniel Kaufmann,Andrés Finzi,Andrés Finzi +24 more
TL;DR: In this article, the presence of SARS-CoV-2-specific memory B cells in convalescent individuals was evaluated using a longitudinal assessment of humoral immune responses.
Journal ArticleDOI
An Asymmetric Opening of HIV-1 Envelope Mediates Antibody-Dependent Cellular Cytotoxicity.
Nirmin Alsahafi,Nordine Bakouche,Mohsen Kazemi,Jonathan Richard,Shilei Ding,Sudipta Bhattacharyya,Durba Das,Sai Priya Anand,Jérémie Prévost,William D. Tolbert,Hong Lu,Halima Medjahed,Gabrielle Gendron-Lepage,Gloria G. Delgado,Sharon Kirk,Bruno Melillo,Walther Mothes,Joseph Sodroski,Amos B. Smith,Daniel Kaufmann,Xueling Wu,Marzena Pazgier,Isabelle Rouiller,Andrés Finzi,Andrés Finzi,James B. Munro +25 more
TL;DR: An asymmetric Env conformation (State 2A) is uncovered recognized by antibodies targeting the conserved gp120 inner domain and mediating ADCC, which may represent approaches to fight HIV-1 infection.
Journal ArticleDOI
Altered differentiation is central to HIV-specific CD4+ T cell dysfunction in progressive disease.
Antigoni Morou,Elsa Brunet-Ratnasingham,Mathieu Dubé,Roxanne Charlebois,Eloi Mercier,Sam Darko,Nathalie Brassard,Krystelle Nganou-Makamdop,Sahaana Arumugam,Gabrielle Gendron-Lepage,Lifei Yang,Julia Niessl,Amy E. Baxter,James M. Billingsley,Premeela A. Rajakumar,Francois Lefebvre,R. Paul Johnson,Cécile Tremblay,Jean-Pierre Routy,Richard T. Wyatt,Andrés Finzi,Daniel C. Douek,Daniel Kaufmann +22 more
TL;DR: It is demonstrated that HIV infection results in an alterated differentation of HIV-specific CD4+ T cells that is only partially reversed by antiretroviral therapy and generation of dysfunctional T cells with a follicular helper-like phenotype.