S
Shin-ichi Muramatsu
Researcher at Jichi Medical University
Publications - 189
Citations - 6916
Shin-ichi Muramatsu is an academic researcher from Jichi Medical University. The author has contributed to research in topics: Dopamine & Adeno-associated virus. The author has an hindex of 40, co-authored 165 publications receiving 5972 citations. Previous affiliations of Shin-ichi Muramatsu include Meijo University & National Institutes of Health.
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Journal ArticleDOI
Ablation of NMDA Receptors Enhances the Excitability of Hippocampal CA3 Neurons
Fumiaki Fukushima,Kazuhito Nakao,Toru Shinoe,Masahiro Fukaya,Shin-ichi Muramatsu,Kenji Sakimura,Hirotaka Kataoka,Hisashi Mori,Masahiko Watanabe,Toshiya Manabe,Masayoshi Mishina +10 more
TL;DR: It is raised an intriguing possibility that hippocampal CA3 NMDA receptors may suppress the excitability of the recurrent network as a whole in vivo by restricting synchronous firing of CA3 neurons.
Journal ArticleDOI
Identification of the plasminogen activator inhibitor-1 binding heptapeptide in vitronectin.
Jun Mimuro,Shin-ichi Muramatsu,Yoshihiro Kurano,Yoshiaki Uchida,Hiroyuki Ikadai,Shunichi Watanabe,Yoichi Sakata +6 more
TL;DR: Data indicated that VN residues Gly-115-Glu-121 contain a PAI-1 binding site, which is equivalent to intact VN, although a 1000-fold higher molar concentration of V-111 over VN was required.
Book ChapterDOI
Gene therapy of Parkinson's disease using adeno-associated virus (AAV) vectors.
Keiya Ozawa,D.-S. Fan,Y. Shen,Shin-ichi Muramatsu,K. Fujimoto,Kunihiko Ikeguchi,M. Ogawa,Masashi Urabe,Akihiro Kume,Imaharu Nakano +9 more
TL;DR: In this article, a promising approach to the gene theraphy of PD is instratiatal expression of dopamine-synthesizing enzymes [tyrosine hydroxylase (TH) and aromatic L-amino acid decarboxylase(AADC)].
Journal ArticleDOI
A Neuron-Specific Gene Therapy Relieves Motor Deficits in Pompe Disease Mice
Ni-Chung Lee,Wuh-Liang Hwu,Shin-ichi Muramatsu,Shin-ichi Muramatsu,Darin J. Falk,Barry J. Byrne,Chia-Hao Cheng,Nien Chu Shih,Kai-Ling Chang,Li-Kai Tsai,Yin-Hsiu Chien +10 more
TL;DR: A neuron-specific gene therapy improved the motor coordination of Pompe mice by lowering glycogen accumulation, decreasing astrogliosis, and increasing myelination, indicating that neurological deficits are responsible for a significant burden in Pompe disease.
Journal ArticleDOI
Promoting Axon Regeneration in Adult CNS by Targeting Liver Kinase B1
Yosuke Ohtake,Armin Sami,Xinpei Jiang,Makoto Horiuchi,Kieran Slattery,Lena Ma,George M. Smith,Michael E. Selzer,Shin-ichi Muramatsu,Shuxin Li +9 more
TL;DR: It is demonstrated that LKB1 used AMPKα, NUAK1, and ERK as the downstream effectors in the cortex of adult mice and may be an important molecular target in the treatment of CNS injuries.