S
Shin-ichi Muramatsu
Researcher at Jichi Medical University
Publications - 189
Citations - 6916
Shin-ichi Muramatsu is an academic researcher from Jichi Medical University. The author has contributed to research in topics: Dopamine & Adeno-associated virus. The author has an hindex of 40, co-authored 165 publications receiving 5972 citations. Previous affiliations of Shin-ichi Muramatsu include Meijo University & National Institutes of Health.
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Journal ArticleDOI
Delayed delivery of AAV-GDNF prevents nigral neurodegeneration and promotes functional recovery in a rat model of Parkinson's disease
L Wang,Shin-ichi Muramatsu,Y Lu,Kunihiko Ikeguchi,K. Fujimoto,Takashi Okada,Hiroaki Mizukami,Yutaka Hanazono,Akihiro Kume,Fumi Urano,Hiroshi Ichinose,Toshiharu Nagatsu,Imaharu Nakano,Keiya Ozawa +13 more
TL;DR: Significant behavioral recovery was observed from 4–20 weeks following AAV-GDNFflag injection, indicating that a delayed delivery of GDNF gene using AAV vector is efficacious even 4 weeks after the onset of progressive degeneration in a rat model of PD.
Journal ArticleDOI
Nucleotide Sequencing and Generation of an Infectious Clone of Adeno-Associated Virus 3
TL;DR: The results suggest that AAV-3 not only consists of serologically distinct structural proteins but that viral propagation also may be controlled by different gene regulatory elements at the transcription level.
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Selective loss of nigral dopamine neurons induced by overexpression of truncated human alpha-synuclein in mice.
Masaki Wakamatsu,Aiko Ishii,Shingo Iwata,Junko Sakagami,Yuriko Ukai,Mieko Ono,Daiji Kanbe,Shin-ichi Muramatsu,Kazuto Kobayashi,Takeshi Iwatsubo,Makoto Yoshimoto +10 more
TL;DR: The results indicate that truncated human alpha-synuclein is deleterious to the development and/or survival of nigral dopaminergic neurons.
Journal ArticleDOI
Viral delivery of miR-196a ameliorates the SBMA phenotype via the silencing of CELF2
Yu Miyazaki,Hiroaki Adachi,Masahisa Katsuno,Makoto Minamiyama,Yue-Mei Jiang,Zhe Huang,Hideki Doi,Shinjiro Matsumoto,Naohide Kondo,Madoka Iida,Genki Tohnai,Fumiaki Tanaka,Shin-ichi Muramatsu,Gen Sobue +13 more
TL;DR: The early intervention of miR-196a delivered by an AAV vector ameliorated the SBMA phenotypes in a mouse model and establishes the proof of principle that disease-specific miRNA delivery could be useful in neurodegenerative diseases.
Journal ArticleDOI
Anterograde C1ql1 Signaling Is Required in Order to Determine and Maintain a Single-Winner Climbing Fiber in the Mouse Cerebellum
Wataru Kakegawa,Nikolaos Mitakidis,Eriko Miura,Manabu Abe,Keiko Matsuda,Yukari H. Takeo,Kazuhisa Kohda,Junko Motohashi,Akiyo Takahashi,Soichi Nagao,Shin-ichi Muramatsu,Masahiko Watanabe,Kenji Sakimura,A. Radu Aricescu,Michisuke Yuzaki +14 more
TL;DR: It is shown that C1ql1, a member of the C1q family of proteins, is provided by climbing fibers and serves as a crucial anterograde signal to determine and maintain the single-winner CF in the mouse cerebellum throughout development and adulthood.