S
Shin-ichi Muramatsu
Researcher at Jichi Medical University
Publications - 189
Citations - 6916
Shin-ichi Muramatsu is an academic researcher from Jichi Medical University. The author has contributed to research in topics: Dopamine & Adeno-associated virus. The author has an hindex of 40, co-authored 165 publications receiving 5972 citations. Previous affiliations of Shin-ichi Muramatsu include Meijo University & National Institutes of Health.
Papers
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Journal ArticleDOI
In utero gene therapy rescues microcephaly caused by Pqbp1-hypofunction in neural stem progenitor cells
Hikaru Ito,Hiroki Shiwaku,Chisato Yoshida,Hidenori Homma,Hong Luo,Xigui Chen,Kyota Fujita,Luciana Musante,Ute Fischer,Suzanna G.M. Frints,Corrado Romano,Yoshiho Ikeuchi,Teppei Shimamura,Seiya Imoto,Satoru Miyano,Shin-ichi Muramatsu,Takeshi Kawauchi,Mikio Hoshino,Marius Sudol,Anup Arumughan,Erich E. Wanker,Tina Rich,Charles E. Schwartz,Fumio Matsuzaki,Azad Bonni,Vera M. Kalscheuer,Hitoshi Okazawa +26 more
TL;DR: Exogenous Apc4, a hub protein in the network of affected genes, recovered the cell cycle, proliferation, and cell phenotypes of NSPCs caused by Pqbp1-cKO and reveals a mechanism of brain size control based on the simple reduction of the NSPC pool by cell cycle time elongation.
Journal ArticleDOI
Current status of Kampo medicine curricula in all Japanese medical schools
Makoto Arai,Shuichi Katai,Shin-ichi Muramatsu,Takao Namiki,Toshihiko Hanawa,Shun-ichiro Izumi +5 more
TL;DR: Japanese medical schools only offer students a short time to study Kampo Medicine, and the impetus to include Kampo medicine in their curricula varies among schools, so future Kampo education at medical schools requires solving several problems, including curriculum standardization.
Patent
Adeno-Associated Virus Virion for Gene Transfer to Nervous System Cells
TL;DR: In this article, the authors presented a means for transferring a therapeutic gene of interest into a nervous system cell by a highly efficient and simpler means, using recombinant adeno-associated virus (AAV) virions.
Journal ArticleDOI
Artificial association of memory events by optogenetic stimulation of hippocampal CA3 cell ensembles
Naoya Oishi,Masanori Nomoto,Noriaki Ohkawa,Yoshito Saitoh,Yoshitake Sano,Yoshitake Sano,Shuhei Tsujimura,Hirofumi Nishizono,Mina Matsuo,Shin-ichi Muramatsu,Shin-ichi Muramatsu,Kaoru Inokuchi +11 more
TL;DR: In vivo electrophysiological recordings showed that 20-Hz optical stimulation of ChR2-mCherry-expressing CA3 neurons, which is the same stimulation protocol used in behavioral experiment, induced long-term potentiation at CA3-CA3 synapses.
Journal ArticleDOI
Long-term efficacy and safety of eladocageneexuparvovec in patients with AADC deficiency
Katherine Ada Twede,Chun-Hwei Tai,Ni-Chung Lee,Yin-Hsiu Chien,Barry J. Byrne,Shin-ichi Muramatsu,Shin-ichi Muramatsu,Sheng-Hong Tseng,Wuh-Liang Hwu +8 more
TL;DR: In this article, the human aromatic L-amino acid decarboxylase gene (eladocagene exuparvovec) was used for gene therapy.