S
Shin-ichi Muramatsu
Researcher at Jichi Medical University
Publications - 189
Citations - 6916
Shin-ichi Muramatsu is an academic researcher from Jichi Medical University. The author has contributed to research in topics: Dopamine & Adeno-associated virus. The author has an hindex of 40, co-authored 165 publications receiving 5972 citations. Previous affiliations of Shin-ichi Muramatsu include Meijo University & National Institutes of Health.
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Adeno-associated virus (AAV)-3-based vectors transduce haematopoietic cells not susceptible to transduction with AAV-2-based vectors
TL;DR: Compared to recombinant (r) AAV-2, rAAV-3 successfully transduced erythroid and megakaryoblastoid cells, although rAAv-2 was superior in transduction of lymphocyte-derived cell lines and the transduction efficiencies were compared.
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Synapse-specific representation of the identity of overlapping memory engrams
Kareem Abdou,Mohammad Shehata,Kiriko Choko,Hirofumi Nishizono,Mina Matsuo,Shin-ichi Muramatsu,Shin-ichi Muramatsu,Kaoru Inokuchi +7 more
TL;DR: It was found that after complete retrograde amnesia of auditory fear conditioning in mice, optogenetic stimulation of the auditory inputs to the lateral amygdala failed to induce memory recall, implying that the memory engram no longer existed in that circuit.
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Semibiological molecular machine with an implemented "AND" logic gate for regulation of protein folding.
TL;DR: Implementation of such "AND" logic gate mechanisms in mechanically driven biomolecular systems is an important step toward the design of secured drug delivery systems.
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CRISPR/Cas9-mediated genome editing via postnatal administration of AAV vector cures haemophilia B mice
Tsukasa Ohmori,Yasumitsu Nagao,Hiroaki Mizukami,Asuka Sakata,Shin-ichi Muramatsu,Shin-ichi Muramatsu,Keiya Ozawa,Shin-ichi Tominaga,Yutaka Hanazono,Satoshi Nishimura,Satoshi Nishimura,Osamu Nureki,Yoichi Sakata +12 more
TL;DR: The results suggest that CRISPR/Cas9-mediated genome editing using an AAV8 vector provides a flexible approach to induce DSB at target genes in hepatocytes and could be a good strategy for haemophilia gene therapy.
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Persistent Expression of Dopamine-Synthesizing Enzymes 15 Years After Gene Transfer in a Primate Model of Parkinson's Disease.
Yoshihide Sehara,Ken-ichi Fujimoto,Kunihiko Ikeguchi,Yuko Katakai,Fumiko Ono,Naomi Takino,Mika Ito,Keiya Ozawa,Shin-ichi Muramatsu,Shin-ichi Muramatsu +9 more
TL;DR: Evidence of long-term safety and efficacy of the triple-transduction method as a gene therapy for PD is provided.