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Shin-ichi Muramatsu
Researcher at Jichi Medical University
Publications - 189
Citations - 6916
Shin-ichi Muramatsu is an academic researcher from Jichi Medical University. The author has contributed to research in topics: Dopamine & Adeno-associated virus. The author has an hindex of 40, co-authored 165 publications receiving 5972 citations. Previous affiliations of Shin-ichi Muramatsu include Meijo University & National Institutes of Health.
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Journal ArticleDOI
Choreiform movements in spinocerebellar ataxia type 1.
Michito Namekawa,Yoshihisa Takiyama,Yoshihito Ando,Kumi Sakoe,Shin-ichi Muramatsu,Ken-ichi Fujimoto,Masatoyo Nishizawa,Imaharu Nakano +7 more
TL;DR: If "sporadic" cases of cerebellar ataxia show such movements, the possibility of genetic origin of the ataxIA is high and a surveillance of various forms of hereditary spinocerebellarAtaxia including SCA1 is required.
Journal ArticleDOI
Gene Therapy in a Mouse Model of Niemann-Pick Disease Type C1.
Yoshie Kurokawa,Hitoshi Osaka,Takeshi Kouga,Eriko F. Jimbo,Kazuhiro Muramatsu,Sachie Nakamura,Yuki Takayanagi,Tatsushi Onaka,Shin-ichi Muramatsu,Takanori Yamagata +9 more
TL;DR: The results suggest the feasibility of gene therapy for patients with NPC1, and combined injection into both the lateral ventricle and cisterna magna achieved broader delivery of the vector to the CNS, leading to better outcomes than noted in previous reports.
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RpA1 ameliorates symptoms of mutant ataxin-1 knock-in mice and enhances DNA damage repair
Juliana Bosso Taniguchi,Kanoh Kondo,Kyota Fujita,Xigui Chen,Hidenori Homma,Takeaki Sudo,Ying Mao,Kei Watase,Toshihiro Tanaka,Kazuhiko Tagawa,Takuya Tamura,Shin-ichi Muramatsu,Shin-ichi Muramatsu,Hitoshi Okazawa +13 more
TL;DR: Results suggested a possibility of gene therapy with RpA1 for SCA1 and indirectly recovered multiple cellular functions such as RNA splicing, transcription and cell cycle as well as abnormal morphology of dendrite and dendritic spine of Purkinje cells in Atxn1-KI mice.
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Targeted expression of step-function opsins in transgenic rats for optogenetic studies.
Hiroyuki Igarashi,Keiko Ikeda,Keiko Ikeda,Hiroshi Onimaru,Ryosuke Kaneko,Kyo Koizumi,Kaoru Beppu,Kayo Nishizawa,Yukari Takahashi,Fusao Kato,Ko Matsui,Kazuto Kobayashi,Yuchio Yanagawa,Shin-ichi Muramatsu,Toru Ishizuka,Hiromu Yawo +15 more
TL;DR: This transgenic rat actuator/reporter system should facilitate optogenetic studies involving the effective in vivo manipulation of the activities of specific cell fractions using light of minimal intensity.
Journal ArticleDOI
Knockdown of dopamine D2 receptors in the nucleus accumbens core suppresses methamphetamine-induced behaviors and signal transduction in mice
TL;DR: Findings suggest that a D2 receptor-mediated neuronal pathway from the nucleus accumbens core plays an inhibitory role in the development of reinforcing properties.