S
Shin-ichiro Fujiwara
Researcher at Jichi Medical University
Publications - 121
Citations - 5737
Shin-ichiro Fujiwara is an academic researcher from Jichi Medical University. The author has contributed to research in topics: Transplantation & Hematopoietic stem cell transplantation. The author has an hindex of 14, co-authored 107 publications receiving 5134 citations.
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Journal ArticleDOI
Identification of the transforming EML4–ALK fusion gene in non-small-cell lung cancer
Manabu Soda,Young Lim Choi,Munehiro Enomoto,Shuji Takada,Yoshihiro Yamashita,Shunpei Ishikawa,Shin-ichiro Fujiwara,Hideki Watanabe,Kentaro Kurashina,Hisashi Hatanaka,Masashi Bando,Shoji Ohno,Yuichi Ishikawa,Hiroyuki Aburatani,Toshiro Niki,Yasunori Sohara,Yukihiko Sugiyama,Hiroyuki Mano +17 more
TL;DR: It is shown that a small inversion within chromosome 2p results in the formation of a fusion gene comprising portions of the echinoderm microtubule-associated protein-like 4 (EML4) gene and the anaplastic lymphoma kinase (ALK) gene in non-small-cell lung cancer (NSCLC) cells.
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Epigenetic silencing of AXIN2 in colorectal carcinoma with microsatellite instability.
Koji Koinuma,Yoshihiro Yamashita,Wanguo Liu,Hisashi Hatanaka,Kentaro Kurashina,Tomoaki Wada,Shuji Takada,Ruri Kaneda,Young Lim Choi,Shin-ichiro Fujiwara,Miyakura Y,Hideo Nagai,Hiroyuki Mano +12 more
TL;DR: In this paper, the authors compared transcriptomes between colorectal carcinomas (CRCs) with the use of high-density oligonucleotide microarrays harboring >44,000 probe sets.
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Proteomic analysis of hematopoietic stem cell-like fractions in leukemic disorders.
Jun Ota,Yoshihiro Yamashita,Katsuya Okawa,Hiroyuki Kisanuki,Shin-ichiro Fujiwara,Madoka Ishikawa,Young Lim Choi,Shuichi Ueno,Ruri Ohki,Koji Koinuma,Tomoaki Wada,Duane A. Compton,Toshihiko Kadoya,Hiroyuki Mano +13 more
TL;DR: The potential of proteome analysis with background-matched cell fractions obtained from fresh clinical specimens to provide insight into the mechanism of human leukemogenesis is demonstrated.
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Rituximab plus 70% cyclophosphamide, doxorubicin, vincristine and prednisone for Japanese patients with diffuse large B-cell lymphoma aged 70 years and older.
Akiko Meguro,Katsutoshi Ozaki,Kazuya Sato,Iekuni Oh,Shin-ichiro Fujiwara,Rie Hosonuma,Miyuki Sasazaki,Yuji Kikuchi,Yuji Hirata,Chihiro Yamamoto,Mitsuyo Uesawa,Hiroyuki Kobayashi,Haruko Matsu,Hiroshi Okabe,Eisuke Uehara,Akinori Nishikawa,Raine Tatara,Kaoru Hatano,Chizuru Yamamoto,Tomohiro Matsuyama,Masaki Toshima,Masuzu Ueda,Ken Ohmine,Takahiro Suzuki,Masaki Mori,Tadashi Nagai,Kazuo Muroi,Keiya Ozawa +27 more
TL;DR: Three-year PFS with R-70%CHOP for patients aged 70 years and older was not significantly worse than that with full-dose R-CHop for younger patients, suggesting that R- 70% CHOP might be a reasonable choice for patients with DLBCL aged 70 year and older, especially for those with comorbidities.
Journal ArticleDOI
Analysis of the cost-effectiveness of treatment strategies for CML with incorporation of treatment discontinuation.
Chihiro Yamamoto,Hirotomo Nakashima,Takashi Ikeda,Shin-Ichiro Kawaguchi,Yumiko Toda,Shoko Ito,Kiyomi Mashima,Takashi Nagayama,Kento Umino,Daisuke Minakata,Hirofumi Nakano,Kaoru Morita,Ryoko Yamasaki,Miyuki Sugimoto,Yuko Ishihara,Masahiro Ashizawa,Kaoru Hatano,Kazuya Sato,Iekuni Oh,Shin-ichiro Fujiwara,Masuzu Ueda,Ken Ohmine,Kazuo Muroi,Yoshinobu Kanda +23 more
TL;DR: Imatinib first was shown to be the most cost-effective approach even with the incorporation of stop TKI, and the results were robust to univariate and multivariate sensitivity analyses.