Shinae Kizaka-Kondoh

TL;DR: A strategy to create FLAPs bearing dual CDR‐derived peptides (D‐FLAPs) using the anti‐human epithelial growth factor receptor type 2 (HER2) mAb trastuzumab as a basis is developed and is found to bind HER2 with a dissociation constant of 58 nm.

TL;DR: A fusion protein drug, PTD-ODD-Procaspase-3 that selectively induces cell death in HIF-1-active/hypoxic cells is developed and in vivo imaging systems capable of monitoring Hif-1 activity in transplanted human cancer cells in mice are useful in evaluating the efficiency of these drugs and in study of H IF- 1-active tumor cells.

TL;DR: Transgenic mice that carry HRE/ODD-luciferase gene, which generates bioluminescence in an HIF-1-dependent manner and was successfully used in this study to monitor Hif-1 activity in ischemic tissues, suggest that the Tg mouse lines hold significant potential for monitoring the early onset of both ischemia and carcinogenesis.

TL;DR: High-resolution SPECT images successfully demonstrated heterogeneous intratumoral distribution of 125I-IPOS, a 125I labeled chimeric protein probe that would visualize HIF activity in tumor tissues in vivo.

TL;DR: This study proposes a technique to achieve a uniform distribution of cells using a micropillar array inside a microchamber, and finds that this technique will be helpful for reproducing results in cellular research at the micro scale or for those using microfluidic devices.