Shinae Kizaka-Kondoh

TL;DR: The bioluminescence produced by AkaLumine-HCl in reactions with native firefly luciferase is in the near-infrared wavelength ranges, and yields significantly increased target-detection sensitivity from deep tissues with maximal signals attained at very low concentrations, as compared with D-luciferin and emerging synthetic luciferin CycLuc1.

TL;DR: The results suggest that the combination of protein therapy using a cytotoxic TAT-ODD fusion protein with radiotherapy and chemotherapy may provide a new strategy for annihilating solid tumors.

TL;DR: Results indicate that Akt/mTOR-dependent translation of HIF-1α plays a critical role in the postirradiation up-regulation of intratumoral Hif-1 activity in response to radiation-induced alterations of glucose and oxygen availability in a solid tumor.

TL;DR: In vivo fluorescence imaging specifically detected GPU-167 in tumors 24 h after administration and ex vivo analysis revealed that fluorescence showed a strong correlation with hypoxia inducible factor (HIF)-1 active hypoxic regions, suggesting thatGPU-167 is a promising in vivo optical imaging probe for tumor hypoxIA.

TL;DR: It is suggested that CCR1 antagonists can provide antimetastatic therapies for patients with disseminated colon cancer in the liver because of their role in tumor invasion and metastasis.