S
Shinae Kizaka-Kondoh
Researcher at Tokyo Institute of Technology
Publications - 110
Citations - 4936
Shinae Kizaka-Kondoh is an academic researcher from Tokyo Institute of Technology. The author has contributed to research in topics: Tumor hypoxia & Gene. The author has an hindex of 36, co-authored 102 publications receiving 4399 citations. Previous affiliations of Shinae Kizaka-Kondoh include Kyoto University.
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Journal ArticleDOI
MT1-MMP plays a critical role in hematopoiesis by regulating HIF-mediated chemokine/cytokine gene transcription within niche cells
Chiemi Nishida,Kaori Kusubata,Yoshihiko Tashiro,Ismael Gritli,Aki Sato,Makiko Ohki-Koizumi,Yohei Morita,Makoto Nagano,Takeharu Sakamoto,Naohiko Koshikawa,Takahiro Kuchimaru,Shinae Kizaka-Kondoh,Motoharu Seiki,Hiromitsu Nakauchi,Beate Heissig,Beate Heissig,Koichi Hattori,Koichi Hattori +17 more
TL;DR: Membrane-type 1 matrix metalloproteinase in niche cells regulates postnatal hematopoiesis, by modulating he matopoietic HIF-dependent niche factors that are critical for terminal differentiation and migration.
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Identification of a Series of Transforming Growth Factor β-Responsive Genes by Retrovirus-Mediated Gene Trap Screening
TL;DR: In this article, a retrovirus-mediated gene trap screening was performed to identify genes responsible for maintaining the phenotype induced by transforming growth factor beta (TGF-beta) in lung carcinoma cell line A549.
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Hypoxia inducible factor-1 influences sensitivity to paclitaxel of human lung cancer cell lines under normoxic conditions.
Lihua Zeng,Shinae Kizaka-Kondoh,Satoshi Itasaka,Xuejun Xie,Masahiro Inoue,Keiji Tanimoto,Keiko Shibuya,Masahiro Hiraoka +7 more
TL;DR: Data support the potential development of HIF‐1 targeted approaches in combination with PTX, where drug resistance tends to contribute to treatment failure.
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TS-1 enhances the effect of radiotherapy by suppressing radiation-induced hypoxia-inducible factor-1 activation and inducing endothelial cell apoptosis.
Lihua Zeng,Lihua Zeng,Guangfei Ou,Satoshi Itasaka,Hiroshi Harada,Xuejun Xie,Xuejun Xie,Keiko Shibuya,Shinae Kizaka-Kondoh,Akiyo Morinibu,Kazumi Shinomiya,Masahiro Hiraoka +11 more
TL;DR: Results indicate that TS‐1 enhances radiation‐induced apoptosis of endothelial cells by suppressing HIF‐1 activity, resulting in an increase in radiosensitivity of the tumor cells.
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Persisting mild hypothermia suppresses hypoxia-inducible factor-1α protein synthesis and hypoxia-inducible factor-1-mediated gene expression
Tomoharu Tanaka,Takuhiko Wakamatsu,Hiroki Daijo,Seiko Oda,Shinichi Kai,Takehiko Adachi,Shinae Kizaka-Kondoh,Kazuhiko Fukuda,Kiichi Hirota +8 more
TL;DR: The transcription factor hypoxia-inducible factor-1 (HIF-1) plays an essential role in regulating gene expression in response to hypoxias-ischemia as discussed by the authors.