S
Shinae Kizaka-Kondoh
Researcher at Tokyo Institute of Technology
Publications - 110
Citations - 4936
Shinae Kizaka-Kondoh is an academic researcher from Tokyo Institute of Technology. The author has contributed to research in topics: Tumor hypoxia & Gene. The author has an hindex of 36, co-authored 102 publications receiving 4399 citations. Previous affiliations of Shinae Kizaka-Kondoh include Kyoto University.
Papers
More filters
Journal ArticleDOI
In vivo imaging of HIF-active tumors by an oxygen-dependent degradation protein probe with an interchangeable labeling system.
Takahiro Kuchimaru,Tetsuya Kadonosono,Shotaro Tanaka,Takashi Ushiki,Masahiro Hiraoka,Shinae Kizaka-Kondoh +5 more
TL;DR: Results indicate that POH is a practical probe specific to Hif-active cell in cancers and suggest its large potential for imaging and targeting of HIF-related diseases.
Journal ArticleDOI
Functional molecular imaging of ILK-mediated Akt/PKB signaling cascades and the associated role of beta-parvin.
Mariko Kimura,Takashi Murakami,Shinae Kizaka-Kondoh,Masayuki Itoh,Keiji Yamamoto,Yukihiro Hojo,Makoto Takano,Kazuomi Kario,Kazuyuki Shimada,Eiji Kobayashi +9 more
TL;DR: Functional molecular imaging demonstrated that β-parvin plays a regulatory role in the ILK-mediated Akt (also called protein kinase B) signaling cascades, suggesting thatβ- parvin might be a crucial modulator of cell survival.
Journal ArticleDOI
Enhanced Percolation and Gene Expression in Tumor Hypoxia by PEGylated Polyplex Micelles
Muri Han,Makoto Oba,Nobuhiro Nishiyama,Mitsunobu R. Kano,Shinae Kizaka-Kondoh,Kazunori Kataoka +5 more
TL;DR: It is demonstrated for the first time that polyplex micelles might show improved tumor penetrability over cationic polyplexes, thereby achieving transfection into the inside of the tumor tissue.
Journal ArticleDOI
CrkII signals from epidermal growth factor receptor to Ras.
TL;DR: It is concluded that adapter molecules are highly specific and that the oncogenic growth signal from epidermal growth factor receptor to Ras is predominantly mediated by CrkII in rat fibroblast.
Journal ArticleDOI
A hypoxia-inducible factor (HIF)-3α splicing variant, HIF-3α4 impairs angiogenesis in hypervascular malignant meningiomas with epigenetically silenced HIF-3α4.
Hitoshi Ando,Atsushi Natsume,Kenichiro Iwami,Fumiharu Ohka,Takahiro Kuchimaru,Shinae Kizaka-Kondoh,Kengo Ito,Kiyoshi Saito,Sachi Sugita,Tsuneyoshi Hoshino,Toshihiko Wakabayashi +10 more
TL;DR: It is found that the transcription of Hif-3α4 was silenced by the promoter DNA methylation in meningiomas, and inducible HIF-3 α4 impaired angiogenesis, proliferation, and metabolism/oxidation in hypervascular mening iomas.