S
Shinae Kizaka-Kondoh
Researcher at Tokyo Institute of Technology
Publications - 110
Citations - 4936
Shinae Kizaka-Kondoh is an academic researcher from Tokyo Institute of Technology. The author has contributed to research in topics: Tumor hypoxia & Gene. The author has an hindex of 36, co-authored 102 publications receiving 4399 citations. Previous affiliations of Shinae Kizaka-Kondoh include Kyoto University.
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Role of TGF-β in EGF-induced transformation of NRK cells is sustaining high-level EGF-signaling1
TL;DR: The findings suggest that the major role of TGF‐β in this transformation system should be to counteract the ligand‐dependent down‐regulation of EGFR, thereby sustaining high‐level EGF‐signaling.
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Novel adherent CD11b+ Gr-1+ tumor-infiltrating cells initiate an immunosuppressive tumor microenvironment.
Takuya Tsubaki,Tetsuya Kadonosono,Shimon Sakurai,Tadashi Shiozawa,Toshiki Goto,Shiori Sakai,Takahiro Kuchimaru,Takeharu Sakamoto,Hitomi Watanabe,Gen Kondoh,Shinae Kizaka-Kondoh +10 more
TL;DR: It is suggested that MLACs may function as an initiator of the immunosuppressive tumor microenvironment and highlight a new therapeutic target to prevent the onset or delay malignant progression.
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Strategic design to create HER2-targeting proteins with target-binding peptides immobilized on a fibronectin type III domain scaffold
Wanaporn Yimchuen,Tetsuya Kadonosono,Yumi Ota,Shinichi Sato,Maika Kitazawa,Tadashi Shiozawa,Takahiro Kuchimaru,Masumi Taki,Yuji Ito,Hiroyuki Nakamura,Shinae Kizaka-Kondoh +10 more
TL;DR: HBP-FLAP containing the YCAHNM peptide showed increased proteolysis-resistance, binding to HER2 with a dissociation constant (KD) of 58 nM in ELISA and 287NM in biolayer interferometry and specifically detects HER2-expressing cancer cells.
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Slicing Spheroids in Microfluidic Devices for Morphological and Immunohistochemical Analysis
TL;DR: A microfluidic device created from embedding resin for sectioning spheroids and according to morphological and immunohistochemical analyses of the slices of the spheroid, specific protein distribution was observed.
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Microfluidic Device for Screening for Target Cell-Specific Binding Molecules by Using Adherent Cells
TL;DR: A microfluidic device for screening molecules such as aptamers, antibodies, proteins, etc. for target cell-specific binding molecules and showed that the device could reduce anti-integrin antibodies to the detection limit of fluorescent measurement and collect anti-HER2 antibodies from the target cells.