Shinae Kizaka-Kondoh

TL;DR: It is concluded that muscarinic acetylcholine signals activate HIF-1 by both stabilization and synthesis of Hif-1α and by inducing the transcriptional activity of HIF -1α.

TL;DR: A novel HIF-1-dependent reporter gene is constructed, 5HREp-ODD-luc, in which 5 copies of the hypoxia-response element (5HRE) enhance expression of the oxygen-dependent degradation (ODD) domain and luciferase (luc) fusion under Hypoxia, which will surely accelerate analysis of the intratumoral Hif-1 activity during tumor progression and cancer treatments.

TL;DR: BMMNC treatment provides marked protection against ischemic WM damage, enhancing CBF in the early phase and in subsequent angiogenesis, both of which involve nitric oxide synthase activation.

TL;DR: In this paper, the synthesis of N-methylimidazolium chloride-modified iron oxide nanoparticles (MImCl-NPs) by condensation of an imidazolate cation-containing silane coupling agent was reported.

TL;DR: It is reported that CPP/PTDs facilitate the extravasation of fused proteins by binding to neuropilin-1 (NRP1), a vascular endothelial growth factor co-receptor expressed on the surface of endothelial and some tumor cells.