Shinichi Fukuda

TL;DR: It is demonstrated that RPE degeneration in human-cell-culture and mouse models is driven by a noncanonical-inflammasome pathway that activates caspase-4, gasdermin D, interferon-β, and cGAS levels were elevated in the RPE in human eyes with geographic atrophy, and an unexpected role of cGas in responding to mobile-element transcripts is highlighted.

TL;DR: The visual function parameters associated with VR-QOL are different depending on vitreoretinal disorders, and changes in contrast sensitivity and metamorphopsia were significantly associated with changes in the VFQ-25 composite score in MH and ERM.

TL;DR: The CCT measurements were comparable among CAS-OCT, ultrasonic pachymetry, and scanning-slit topography, but Scheimpflug camera yielded a significantly higher CCT value, and the coefficient of repeatability and reproducibility of CCT and ACD measurements were <5% and ICCs were >0.98.

TL;DR: PS-OCT showed promising for the study and diagnosis diseases related to abnormal fibrous tissues of the cornea and anterior eye segment related to glaucoma patients treated by trabeculectomy and keratoconus cases with advanced thinning and with a rupture of Descemet's membrane.

TL;DR: Vitrectomy for MH significantly improved VFQ-25 composite score as well as subscale scores, including general vision, near activities, distance activities, social functioning, mental health and dependency and the severity of metamorphopsia was significantly associated with both preoperative and postoperative VR-QOL.