S
Shira Perl
Researcher at National Institutes of Health
Publications - 22
Citations - 2726
Shira Perl is an academic researcher from National Institutes of Health. The author has contributed to research in topics: Population & Progenitor cell. The author has an hindex of 12, co-authored 20 publications receiving 2343 citations.
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Journal ArticleDOI
Neurogenesis in the Striatum of the Adult Human Brain
Aurélie Ernst,Kanar Alkass,Samuel Bernard,Mehran Salehpour,Shira Perl,John F. Tisdale,Göran Possnert,Henrik Druid,Jonas Frisén +8 more
TL;DR: It is shown that in adult humans new neurons integrate in the striatum, which is adjacent to this neurogenic niche, and this findings demonstrate a unique pattern of neurogenesis in the adult human brain.
Journal ArticleDOI
Dynamics of oligodendrocyte generation and myelination in the human brain.
Maggie S. Y. Yeung,Sofia Zdunek,Olaf Bergmann,Samuel Bernard,Mehran Salehpour,Kanar Alkass,Shira Perl,John F. Tisdale,Göran Possnert,Lou Brundin,Henrik Druid,Jonas Frisén +11 more
TL;DR: It is concluded that oligodendrocyte turnover contributes minimally to myelin modulation in human white matter and that this instead may be carried out by mature oligodendedrocytes, which may facilitate rapid neural plasticity.
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Global analyses of human immune variation reveal baseline predictors of postvaccination responses.
John S. Tsang,Pamela L. Schwartzberg,Yuri Kotliarov,Angelique Biancotto,Zhi Xie,Ronald N. Germain,Ena Wang,Matthew J. Olnes,Manikandan Narayanan,Hana Golding,Susan Moir,Howard B. Dickler,Shira Perl,Foo Cheung +13 more
TL;DR: Independent of age and pre-existing antibody titers, accurate models could be constructed using pre-perturbation cell populations alone, which were validated using independent baseline time points.
Journal ArticleDOI
The Lifespan and Turnover of Microglia in the Human Brain
Pedro Réu,Pedro Réu,Azadeh Khosravi,Samuel Bernard,Jeff E. Mold,Mehran Salehpour,Kanar Alkass,Shira Perl,John F. Tisdale,Göran Possnert,Henrik Druid,Jonas Frisén +11 more
TL;DR: It is reported that microglia, unlike most other hematopoietic lineages, renew slowly at a median rate of 28% per year, and some microglial progenitor cells last for more than two decades.
Journal ArticleDOI
Cardiomyogenesis in the Adult Human Heart
Jan Kajstura,Konrad Urbanek,Shira Perl,Toru Hosoda,Hanqiao Zheng,Barbara Ogorek,João Ferreira-Martins,Polina Goichberg,Carlos Rondon-Clavo,Fumihiro Sanada,Domenico D'Amario,Marcello Rota,Federica del Monte,Donald Orlic,John F. Tisdale,Annarosa Leri,Piero Anversa +16 more
TL;DR: The findings indicate that the human heart has a significant growth reserve and replaces its myocyte and nonmyocyte compartment several times during the course of life.