Pedro Réu

TL;DR: It is reported that microglia, unlike most other hematopoietic lineages, renew slowly at a median rate of 28% per year, and some microglial progenitor cells last for more than two decades.

TL;DR: It is shown that scarring by neural stem cell–derived astrocytes is required to restrict secondary enlargement of the lesion and further axonal loss after spinal cord injury and one distinct component of the glial scar, deriving from resident neural stem cells, is required for maintaining the integrity of the injured spinal cord.

TL;DR: Accumulation of CD45− PCs during ageing and the presence of rotavirus-specific clones entirely within the CD19− PC subsets support selection and maintenance of protective PCs for life in human intestine.

TL;DR: It is demonstrated that naive T-cell generation decreases with age because of a combination of declining peripheral division and thymic production during adulthood, and an age-related decline in naiveT-cell turnover is revealed and a molecular pathway that restricts proliferation of peripherally expanded naive t-cell clones that accumulate with age is identified.

TL;DR: Conbase leverages phased read data from multiple samples in a dataset to achieve increased confidence in somatic variant calls and genotype predictions and provides superior robustness on simulated data, in vitro expanded fibroblasts and clonal lymphocyte populations isolated directly from a healthy human donor.