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Chunru Lin
Researcher at University of Texas MD Anderson Cancer Center
Publications - 32
Citations - 4619
Chunru Lin is an academic researcher from University of Texas MD Anderson Cancer Center. The author has contributed to research in topics: Cancer & Cancer immunotherapy. The author has an hindex of 20, co-authored 32 publications receiving 3602 citations.
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Journal ArticleDOI
Human polymorphism at microRNAs and microRNA target sites.
Liuqing Yang,Chunru Lin,Chunyu Jin,Joy C. Yang,Bogdan Tanasa,Wenbo Wen-Hsiung Li,Daria Merkurjev,Kenneth a. Ohgi,Jie Zhang,Christopher P. Evans,Michael G. Rosenfeld,Charles E Vejnar,Matthias Blum,Evgeny M. Zdobnov,A Turchinovich,T R Samatov,a G Tonevitsky,B Burwinkel,Georg Schett,Dirk Elewaut,Iain B McInnes,Jean-Michel Dayer,Markus F Neurath,Sachin Pundhir,Jan Gorodkin,Fabiola Olivieri,Maria Rita Rippo,Antonio Domenico Procopio,Francesca Fazioli,Lukas T Jeker,Xuyu Zhou,Robert Blelloch,Jeffrey a Bluestone,Claudiane Guay,Romano Regazzi,Roopali Gandhi,Brian Healy,Taha Gholipour,Svetlana Egorova,Alexander Musallam,Mohammad Shuja Hussain,Parham Nejad,Bonny Patel,Hillary Hei,Samia Khoury,Francisco Quintana,Pia Kivisakk,Tanuja Chitnis,Howard L Weiner,Yun Deng,Jian Zhao,Daisuke Sakurai,Kenneth M. Kaufman,Jeffrey C. Edberg,Robert P. Kimberly,Diane L. Kamen,Gary S. Gilkeson,Chaim O. Jacob,R. Hal Scofield,Carl D. Langefeld,Jennifer A. Kelly,Rosalind Ramsey-Goldman,Michelle Petri,John D. Reveille,Luis M. Vilá,Graciela S. Alarcón,Timothy J. Vyse,Bernardo A. Pons-Estel,Barry I. Freedman,Patrick M. Gaffney,Kathy Moser Sivils,Judith A. James,Peter K. Gregersen,Juan-Manuel Anaya,Timothy B. Niewold,Joan T. Merrill,Lindsey A. Criswell,Anne M. Stevens,Susan A. Boackle,Rita M. Cantor,Weiling Chen,J Grossman,Bevra H. Hahn,John B. Harley,Marta E Alarcόn-Riquelme,Elizabeth E. Brown,Betty P. Tsao,Susan Carpenter,Maninjay Atianand,Daniel Aiello,Emiliano P Ricci,Pallavi Gandhi,Lisa L Hall,Meg Byron,Brian Monks,Meabh Henry-Bezy,Jeanne B Lawrence,Luke a J O'Neill,Melissa J Moore,Daniel R Caffrey,Katherine a Fitzgerald,Dan-Xia Zhu,Lei Fan,Rui-Nan Lu,Cheng Fang,Wen-Yi Shen,Zhi-Jian Zou,Yin-Hua Wang,Hua-Yuan Zhu,Kou-Rong Miao,Peng Liu,Wei Xu,Jian-Yong Li,Jing Gong,Yin Tong,Hong-Mei Zhang,Kai Wang,Tao Hu,Ge Shan,Jun Sun,An-Yuan Guo,V Davalos,C Moutinho,A Villanueva,R Boque,Pedro Silva,F Carneiro,M Esteller,R Stephanie Huang,Eric R. Gamazon,Dana Ziliak,Yujia Wen,Hae Kyung Im,Wei Zhang,Claudia Wing,Shiwei Duan,Wasim K Bleibel,Nancy J. Cox,M. Eileen Dolan,Patrick Brest,Pierre Lapaquette,Mouloud Souidi,Kevin Lebrigand,Annabelle Cesaro,Valérie Vouret-Craviari,Bernard Mari,Pascal Barbry,Jean-François Mosnier,Xavier Hébuterne,Annick Harel-Bellan,Baharia Mograbi,Arlette Darfeuille-Michaud,Paul Hofman,Jonathan Marchini,Bryan Howie,Lucia A. Hindorff,Praveen Sethupathy,Heather a Junkins,Erin M. Ramos,Jayashri P Mehta,Francis S. Collins,Teri A. Manolio,William O.C.M. Cookson,Liming Liang,Gonçalo R. Abecasis,Miriam F. Moffatt,Mark Lathrop,Matthew A. Saunders,Han Liang +168 more
Journal ArticleDOI
The LINK-A lncRNA activates normoxic HIF1α signalling in triple-negative breast cancer
Aifu Lin,Chunlai Li,Zhen Xing,Qingsong Hu,Ke Liang,Leng Han,Cheng Wang,David H. Hawke,Shouyu Wang,Yanyan Zhang,Yongkun Wei,Guolin Ma,Peter K. Park,Jianwei Zhou,Yan Zhou,Zhibin Hu,Yubin Zhou,Jeffery R. Marks,Han Liang,Mien Chie Hung,Chunru Lin,Liuqing Yang +21 more
TL;DR: A cytoplasmic lncRNA is identified, LINK-A, which mediates HB-EGF-triggered, EGFR:GPNMB heterodimer-dependent HIF1α phosphorylation at Tyr 565 and Ser 797 by BRK and LRRK2, respectively, and correlates with triple-negative breast cancer (TNBC), promoting breast cancer glycolysis reprogramming and tumorigenesis.
Journal ArticleDOI
LncRNA directs cooperative epigenetic regulation downstream of chemokine signals
Zhen Xing,Aifu Lin,Chunlai Li,Ke Liang,Shouyu Wang,Yang Liu,Peter K. Park,Li Qin,Yongkun Wei,David H. Hawke,Mien Chie Hung,Chunru Lin,Liuqing Yang +12 more
TL;DR: A role for lncRNA BCAR4 in breast cancer metastasis is reported that is mediated by chemokine-induced binding of BCAR 4 to two transcription factors with extended regulatory consequences that activates a noncanonical Hedgehog/GLI2 transcriptional program that promotes cell migration.
Journal ArticleDOI
Oncogenic lncRNA downregulates cancer cell antigen presentation and intrinsic tumor suppression.
Qingsong Hu,Youqiong Ye,Li Chuan Chan,Yajuan Li,Ke Liang,Aifu Lin,Aifu Lin,Sergey D. Egranov,Yaohua Zhang,Weiya Xia,Jing Gong,Yinghong Pan,Sujash S. Chatterjee,Jun Yao,Kurt W. Evans,Tina K. Nguyen,Peter K. Park,Jiewei Liu,Cristian Coarfa,Sri Ramya Donepudi,Vasanta Putluri,Nagireddy Putluri,Arun Sreekumar,Chandrashekar R. Ambati,David H. Hawke,Jeffrey R. Marks,Preethi H. Gunaratne,Preethi H. Gunaratne,Abigail S. Caudle,Aysegul A. Sahin,Gabriel N. Hortobagyi,Funda Meric-Bernstam,Lieping Chen,Dihua Yu,Mien Chie Hung,Michael A. Curran,Leng Han,Chunru Lin,Liuqing Yang +38 more
TL;DR: LncRNA-dependent downregulation of antigenicity and intrinsic tumor suppression is demonstrated, which provides the basis for developing combinational immunotherapy treatment regimens and early TNBC prevention.
Journal ArticleDOI
A ROR1-HER3-lncRNA signalling axis modulates the Hippo-YAP pathway to regulate bone metastasis
Chunlai Li,Shouyu Wang,Zhen Xing,Aifu Lin,Ke Liang,Jian Song,Qingsong Hu,Jun Yao,Zhongyuan Chen,Zhongyuan Chen,Peter K. Park,David H. Hawke,Jianwei Zhou,Yan Zhou,Shuxing Zhang,Han Liang,Mien Chie Hung,Mien Chie Hung,Gary E. Gallick,Leng Han,Chunru Lin,Liuqing Yang +21 more
TL;DR: The data provide insights into the mechanistic regulation and linkage of the ROR1–HER3 and Hippo–YAP pathway in a cancer-specific context, and also imply valuable therapeutic targets for bone metastasis and possible therapy-resistant tumours.