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Shu Ching Hu
Researcher at University of Washington
Publications - 39
Citations - 1831
Shu Ching Hu is an academic researcher from University of Washington. The author has contributed to research in topics: Dementia & Cognition. The author has an hindex of 17, co-authored 32 publications receiving 1339 citations. Previous affiliations of Shu Ching Hu include Veterans Health Administration.
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Journal ArticleDOI
Plasma exosomal α-synuclein is likely CNS-derived and increased in Parkinson’s disease
Min Shi,Changqin Liu,Travis J. Cook,Kristin M. Bullock,Kristin M. Bullock,Yanchun Zhao,Carmen Ginghina,Yanfei Li,Patrick Aro,Romel P Dator,Chunmei He,Michael J. Hipp,Cyrus P. Zabetian,Cyrus P. Zabetian,Elaine R. Peskind,Elaine R. Peskind,Shu Ching Hu,Shu Ching Hu,Joseph F. Quinn,Douglas Galasko,William A. Banks,William A. Banks,Jing Zhang +22 more
TL;DR: It is discovered that CSF α-synuclein was readily transported to blood, with a small portion being contained in exosomes that are relatively specific to the central nervous system (CNS), which may lead to a more convenient and robust assessment of Parkinson’s disease clinically.
Journal ArticleDOI
APOE, MAPT, and SNCA genes and cognitive performance in Parkinson disease
Ignacio F. Mata,James B. Leverenz,Daniel Weintraub,John Q. Trojanowski,Howard I. Hurtig,Vivianna M. Van Deerlin,Beate Ritz,Rebecca Rausch,Shannon L. Rhodes,Stewart A. Factor,Cathy Wood-Siverio,Joseph F. Quinn,Kathryn A. Chung,Amie Peterson,Alberto J. Espay,Fredy J. Revilla,Johnna Devoto,Shu Ching Hu,Brenna Cholerton,Jia Y. Wan,Thomas J. Montine,Karen L. Edwards,Cyrus P. Zabetian +22 more
TL;DR: The data indicate that the APOE ε4 allele is an important predictor of cognitive function in PD across multiple domains, and among PD patients without dementia, the APoe ε2/ε3/ε4 allele was only associated with lower performance on word list learning and semantic verbal fluency, a pattern more typical of the cognitive deficits seen in early Alzheimer disease than PD.
Journal ArticleDOI
Association of GBA mutations and the E326K polymorphism with motor and cognitive progression in parkinson disease
Marie Y. Davis,Catherine O. Johnson,James B. Leverenz,Daniel Weintraub,John Q. Trojanowski,Alice Chen-Plotkin,Vivianna M. Van Deerlin,Joseph F. Quinn,Joseph F. Quinn,Kathryn A. Chung,Kathryn A. Chung,Amie L. Peterson-Hiller,Amie L. Peterson-Hiller,Liana S. Rosenthal,Ted M. Dawson,Marilyn S. Albert,Jennifer G. Goldman,Glenn T. Stebbins,Bryan Bernard,Zbigniew K. Wszolek,Owen A. Ross,Dennis W. Dickson,David Eidelberg,Paul J. Mattis,Martin Niethammer,Dora Yearout,Shu Ching Hu,Brenna Cholerton,Megan Smith,Ignacio F. Mata,Thomas J. Montine,Karen L. Edwards,Cyrus P. Zabetian +32 more
TL;DR: GBA variants predict a more rapid progression of cognitive dysfunction and motor symptoms in patients with PD, with a greater effect on PIGD than tremor, and influence the heterogeneity in symptom progression observed in PD.
Journal ArticleDOI
GBA Variants are associated with a distinct pattern of cognitive deficits in Parkinson's disease.
Ignacio F. Mata,James B. Leverenz,Daniel Weintraub,Daniel Weintraub,John Q. Trojanowski,Alice Chen-Plotkin,Vivianna M. Van Deerlin,Beate Ritz,Rebecca Rausch,Stewart A. Factor,Cathy Wood-Siverio,Joseph F. Quinn,Kathryn A. Chung,Amie L. Peterson-Hiller,Jennifer G. Goldman,Glenn T. Stebbins,Bryan Bernard,Alberto J. Espay,Fredy J. Revilla,Fredy J. Revilla,Johnna Devoto,Liana S. Rosenthal,Ted M. Dawson,Marilyn S. Albert,Debby W. Tsuang,Haley Huston,Dora Yearout,Shu Ching Hu,Brenna Cholerton,Thomas J. Montine,Karen L. Edwards,Cyrus P. Zabetian +31 more
TL;DR: Loss‐of‐function mutations in the GBA gene are associated with more severe cognitive impairment in PD, but the nature of these deficits is not well understood and whether common GBA polymorphisms influence cognitive performance in PD is not yet known.
Journal ArticleDOI
CNS tau efflux via exosomes is likely increased in Parkinson's disease but not in Alzheimer's disease
Min Shi,Andrej Kovac,Andrej Kovac,Andrej Kovac,Ane Korff,Travis J. Cook,Carmen Ginghina,Kristin M. Bullock,Kristin M. Bullock,Li Yang,Tessandra Stewart,Danfeng Zheng,Danfeng Zheng,Patrick Aro,Anzari Atik,Kathleen F. Kerr,Cyrus P. Zabetian,Cyrus P. Zabetian,Elaine R. Peskind,Elaine R. Peskind,Shu Ching Hu,Shu Ching Hu,Joseph F. Quinn,Douglas Galasko,Thomas J. Montine,William A. Banks,William A. Banks,Jing Zhang,Jing Zhang +28 more
TL;DR: Alzheimer's disease and Parkinson's disease involve tau pathology, where Tau is detectable in blood, but its clearance from neuronal cells and the brain is poorly understood.