Shu Ching Hu

TL;DR: It is discovered that CSF α-synuclein was readily transported to blood, with a small portion being contained in exosomes that are relatively specific to the central nervous system (CNS), which may lead to a more convenient and robust assessment of Parkinson’s disease clinically.

TL;DR: The data indicate that the APOE ε4 allele is an important predictor of cognitive function in PD across multiple domains, and among PD patients without dementia, the APoe ε2/ε3/ε4 allele was only associated with lower performance on word list learning and semantic verbal fluency, a pattern more typical of the cognitive deficits seen in early Alzheimer disease than PD.

TL;DR: GBA variants predict a more rapid progression of cognitive dysfunction and motor symptoms in patients with PD, with a greater effect on PIGD than tremor, and influence the heterogeneity in symptom progression observed in PD.

TL;DR: Loss‐of‐function mutations in the GBA gene are associated with more severe cognitive impairment in PD, but the nature of these deficits is not well understood and whether common GBA polymorphisms influence cognitive performance in PD is not yet known.

TL;DR: Alzheimer's disease and Parkinson's disease involve tau pathology, where Tau is detectable in blood, but its clearance from neuronal cells and the brain is poorly understood.