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Shuang Qiu
Researcher at Zhejiang University
Publications - 23
Citations - 1202
Shuang Qiu is an academic researcher from Zhejiang University. The author has contributed to research in topics: NMDA receptor & Synaptic plasticity. The author has an hindex of 14, co-authored 22 publications receiving 1021 citations. Previous affiliations of Shuang Qiu include University of Toronto & Xi'an Jiaotong University.
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Shikonin circumvents cancer drug resistance by induction of a necroptotic death.
TL;DR: Shikonin, a naturally occurring naphthoquinone, induced a cell death in MCF-7 and HEK293 distinct from apoptosis and characterized with (a) a morphology of necrotic cell death, (b) loss of plasma membrane integrity, loss of mitochondrial membrane potentials, activation of autophagy, but not a contributing factor; (e) elevation of reactive oxygen species with no critical roles contributing to cell death; and (f) the cell death was prevented by a small molecule, necrostatin-1, that specifically
Journal ArticleDOI
An Increase in Synaptic NMDA Receptors in the Insular Cortex Contributes to Neuropathic Pain
Shuang Qiu,Tao Chen,Kohei Koga,Yan-yan Guo,Yan-yan Guo,Hui Xu,Hui Xu,Qian Song,Jie-jie Wang,Giannina Descalzi,Bong-Kiun Kaang,Jianhong Luo,Min Zhuo,Min Zhuo,Min Zhuo,Ming-gao Zhao,Ming-gao Zhao +16 more
TL;DR: It is found that in a mouse model in which peripheral nerve injury leads to the development of neuropathic pain, the insular cortex showed changes in synaptic plasticity, which were associated with a long-term increase in the amount of synaptic N-methyl-d-aspartate receptors, but not that of extrasynaptic NMDARs.
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Honokiol induces a necrotic cell death through the mitochondrial permeability transition pore.
TL;DR: It is shown that honokiol can induce a cell death distinct from apoptosis in HL60, MCF-7, and HEK293 cell lines, and this is the first report to document an induction of mitochondrial permeability transition pore-associated cell death by Honokiol.
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Postsynaptic potentiation of corticospinal projecting neurons in the anterior cingulate cortex after nerve injury
Tao Chen,Tao Chen,Tao Chen,Kohei Koga,Kohei Koga,Giannina Descalzi,Shuang Qiu,Shuang Qiu,Jian Wang,Le Shi Zhang,Zhijian Zhang,Zhijian Zhang,Xiao Bin He,Xin Qin,Fuqiang Xu,Ji Hu,Feng Wei,Richard L. Huganir,Yun-Qing Li,Min Zhuo,Min Zhuo +20 more
TL;DR: It is reported that pyramidal cells in the deep layers of the ACC send direct descending projecting terminals to the dorsal horn of the spinal cord after peripheral nerve injury, and postsynaptic excitatory responses of these descending projecting neurons were significantly enhanced.
Journal ArticleDOI
GluA1 Phosphorylation Contributes to Postsynaptic Amplification of Neuropathic Pain in the Insular Cortex
Shuang Qiu,Ming Zhang,Yan Liu,Yan-yan Guo,Huan Zhao,Qian Song,Ming-gao Zhao,Richard L. Huganir,Jianhong Luo,Hui Xu,Min Zhuo +10 more
TL;DR: The results suggest that the expression of AMPARs is enhanced in the insular cortex after nerve injury by a pathway involving AC1, AKAP79/150, and PKA, and such enhancement may at least in part contribute to behavioral sensitization together with other cortical regions, such as the anterior cingulate and the prefrontal cortices.