Yun-Qing Li

TL;DR: It is found that stimulation in the anterior cingulate cortex (ACC) potentiated spinal excitatory synaptic transmission and this modulation is independent of the RVM, and that such top-down facilitation may contribute to the process of chronic neuropathic pain.

TL;DR: The current study suggests that neuronal and non-neuronal elements should be taken integrally into consideration for nociceptive transmission, and that the intervention of such interaction may offer some novel pain therapeutic strategies.

TL;DR: It is demonstrated that the descending 5-HT system facilitates GRP-GRPR signaling via 5-ht1A to augment itch-specific outputs, and a disruption of crosstalk between 5- HT1A and GRPR may be a useful antipruritic strategy.

TL;DR: It is reported that pyramidal cells in the deep layers of the ACC send direct descending projecting terminals to the dorsal horn of the spinal cord after peripheral nerve injury, and postsynaptic excitatory responses of these descending projecting neurons were significantly enhanced.

TL;DR: By a double-labeling method combining the retrograde tracing of horseradish peroxidase and the immunocytochemical technique, serotonin-, substance P- or leucine-enkephalin-like immunoreactive neurons in the midbrain periaqueductal gray and the nucleus raphe dorsalis of the rat were found to send projection fibers to the central amygdaloid nucleus bilaterally with an ipsilateral dominance.