D
David C. Nickle
Researcher at Merck & Co.
Publications - 75
Citations - 3336
David C. Nickle is an academic researcher from Merck & Co.. The author has contributed to research in topics: Expression quantitative trait loci & Genome-wide association study. The author has an hindex of 24, co-authored 75 publications receiving 2628 citations.
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Journal Article
Persistence of HIV in Gut-Associated Lymphoid Tissue despite Long-Term Antiretroviral Therapy. Commentary
Steven A. Yukl,Joseph K. Wong,Tae-Wook Chun,David C. Nickle,Jesse S. Justement,Jennifer Hartt Meyers,Gregg Roby,Claire W. Hallahan,Shyam Kottilil,Susan Moir,JoAnn M. Mican,James I. Mullins,Douglas J. Ward,Joseph A. Kovacs,Peter J. Mannon,Anthony S. Fauci +15 more
TL;DR: In this article, the authors found incomplete recoveries of CD4 + T cells in the GALT of aviremic, HIV-infected individuals who had received up to 9.9 years of effective antiretroviral therapy.
Journal Article
Elbasvir–Grazoprevir to Treat Hepatitis C Virus Infection in Persons Receiving Opioid Agonist Therapy
Gregory J. Dore,Frederick L. Altice,Alain H. Litwin,Olav Dalgard,Edward Gane,Oren Shibolet,Anne F Luetkemeyer,Ronald Nahass,Cheng Yuan Peng,Brian Conway,Jason Grebely,Anita Y. M. Howe,I.N. Gendrano,Erluo Chen,H.-C. Huang,Frank J. Dutko,David C. Nickle,Bach-Yen Nguyen,Janice Wahl,Eliav Barr,Michael N. Robertson,Heather L. Platt +21 more
TL;DR: Patients with HCV infection who were receiving OAT and treated with elbasvir-grazoprevir had high rates of SVR12, regardless of ongoing drug use, and these results support the removal of drug use as a barrier to interferon-free HCV treatment for patients receiving Oat.
Journal ArticleDOI
Genetic variants associated with susceptibility to idiopathic pulmonary fibrosis in people of European ancestry: a genome-wide association study
Richard J. Allen,Joanne Porte,Rebecca Braybrooke,Carlos Flores,Tasha E. Fingerlin,Justin M. Oldham,Beatriz Guillen-Guio,Shwu-Fan Ma,Tsukasa Okamoto,Alison E. John,Ma'en Obeidat,Ivana V. Yang,Amanda P. Henry,Richard Hubbard,Vidya Navaratnam,Gauri Saini,Norma Thompson,Helen Booth,Simon P. Hart,Michael Hill,Nik Hirani,Toby M. Maher,Robin J. McAnulty,Ann B. Millar,Philip L. Molyneaux,Helen Parfrey,Doris M Rassl,Moira K. B. Whyte,William A. Fahy,Richard P. Marshall,Eunice Oballa,Yohan Bossé,David C. Nickle,Don D. Sin,Wim Timens,Nick Shrine,Ian Sayers,Ian P. Hall,Imre Noth,David A. Schwartz,Martin D. Tobin,Louise V. Wain,Louise V. Wain,R. Gisli Jenkins +43 more
TL;DR: The identification of AKAP13 as a susceptibility gene for IPF increases the prospect of successfully targeting RhoA pathway inhibitors in patients with IPF.
Journal ArticleDOI
Moderate-to-severe asthma in individuals of European ancestry: a genome-wide association study
Nick Shrine,Michael A. Portelli,Catherine John,María Soler Artigas,Neil Bennett,Robert J. Hall,Jon Lewis,Amanda P. Henry,Charlotte K. Billington,Azaz Ahmad,Richard Packer,Dominick E. Shaw,Zara Pogson,Andrew M. Fogarty,Tricia M. McKeever,Amisha Singapuri,Liam G Heaney,Adel H. Mansur,Rekha Chaudhuri,Neil C. Thomson,John W. Holloway,Gabrielle A. Lockett,Peter H. Howarth,Ratko Djukanovic,Jenny Hankinson,Robert Niven,Angela Simpson,Kian Fan Chung,Peter J. Sterk,John D Blakey,Ian M. Adcock,Sile Hu,Yike Guo,Ma'en Obeidat,Don D. Sin,Maarten van den Berge,David C. Nickle,Yohan Bossé,Martin D. Tobin,Martin D. Tobin,Ian P. Hall,Christopher E. Brightling,Louise V. Wain,Louise V. Wain,Ian Sayers +44 more
TL;DR: It is found that substantial shared genetic architecture between mild and moderate-to-severe asthma is found and candidate causal genes in these loci are identified and provide increased insight into this difficult to treat population.
Journal ArticleDOI
Selection on the Human Immunodeficiency Virus Type 1 Proteome following Primary Infection
Yi Liu,John McNevin,Jianhong Cao,Hong Zhao,Indira Genowati,Kim G. Wong,Sherry McLaughlin,Matthew D. McSweyn,Kurt Diem,Claire E. Stevens,Janine Maenza,Hongxia He,David C. Nickle,Daniel Shriner,Sarah Holte,Ann C. Collier,Lawrence Corey,M. Juliana McElrath,James I. Mullins +18 more
TL;DR: An intensive longitudinal study of viral genetic changes and T-cell immunity in one subject at ≤17 time points during his first 3 years of infection and in his infecting partner near the time of transmission confirmed CTLs as a dominant selective force in HIV-1 infection.