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David C. Nickle

Researcher at Merck & Co.

Publications -  75
Citations -  3336

David C. Nickle is an academic researcher from Merck & Co.. The author has contributed to research in topics: Expression quantitative trait loci & Genome-wide association study. The author has an hindex of 24, co-authored 75 publications receiving 2628 citations.

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Journal Article

Persistence of HIV in Gut-Associated Lymphoid Tissue despite Long-Term Antiretroviral Therapy. Commentary

TL;DR: In this article, the authors found incomplete recoveries of CD4 + T cells in the GALT of aviremic, HIV-infected individuals who had received up to 9.9 years of effective antiretroviral therapy.
Journal Article

Elbasvir–Grazoprevir to Treat Hepatitis C Virus Infection in Persons Receiving Opioid Agonist Therapy

TL;DR: Patients with HCV infection who were receiving OAT and treated with elbasvir-grazoprevir had high rates of SVR12, regardless of ongoing drug use, and these results support the removal of drug use as a barrier to interferon-free HCV treatment for patients receiving Oat.
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Genetic variants associated with susceptibility to idiopathic pulmonary fibrosis in people of European ancestry: a genome-wide association study

TL;DR: The identification of AKAP13 as a susceptibility gene for IPF increases the prospect of successfully targeting RhoA pathway inhibitors in patients with IPF.
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Moderate-to-severe asthma in individuals of European ancestry: a genome-wide association study

TL;DR: It is found that substantial shared genetic architecture between mild and moderate-to-severe asthma is found and candidate causal genes in these loci are identified and provide increased insight into this difficult to treat population.
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Selection on the Human Immunodeficiency Virus Type 1 Proteome following Primary Infection

TL;DR: An intensive longitudinal study of viral genetic changes and T-cell immunity in one subject at ≤17 time points during his first 3 years of infection and in his infecting partner near the time of transmission confirmed CTLs as a dominant selective force in HIV-1 infection.