[신간의 별자리x] 우리/미술, 그리고 ‘슬픔의 박물관’

https://cyberleninka.org/article/n/933162.pdf

Hydrogels in drug delivery: progress and challenges

Molecular self-assembly is the spontaneous association of molecules under equilibrium conditions into stable, structurally well-defined aggregates joined by noncovalent bonds. Molecular self-assembly is ubiquitous in biological systems and underlies the formation of a wide variety of complex biological structures. Understanding self-assembly and the associated noncovalent interactions that connect complementary interacting molecular surfaces in biological aggregates is a central concern in structural biochemistry. Self-assembly is also emerging as a new strategy in chemical synthesis, with the potential of generating nonbiological structures with dimensions of 1 to 10(2) nanometers (with molecular weights of 10(4) to 10(10) daltons). Structures in the upper part of this range of sizes are presently inaccessible through chemical synthesis, and the ability to prepare them would open a route to structures comparable in size (and perhaps complementary in function) to those that can be prepared by microlithography and other techniques of microfabrication.

Molecular self-assembly and nanochemistry: A chemical strategy for the synthesis of nanostructures

https://www.farm.ucl.ac.be/Full-texts-FARM/Danhier-2010-2.pdf

To exploit the tumor microenvironment: Passive and active tumor targeting of nanocarriers for anti-cancer drug delivery

/pdf/degradable-controlled-release-polymers-and-polymeric-1y322ha58z.pdf

Degradable Controlled-Release Polymers and Polymeric Nanoparticles: Mechanisms of Controlling Drug Release

Star oligo/poly(trimethylene carbonate)s with cholic acid moieties as cores were synthesized by ring-opening polymerization of trimethylene carbonate (TMC) initiated by cholic acid with hydroxyl groups. The molecular weights of the star oligomers/polymers were controlled by adjusting the feed ratio of the initiator cholic acid to the monomer TMC. The star oligo/poly(trimethylene carbonate)s were characterized by Fourier transform infrared spectroscopy (FT-IR), 1H nuclear magnetic resonance spectroscopy (1H-NMR) and combined size-exclusion chromatography and multiangle laser light scattering (SEC-MALLS) analysis. The water contact angles of the star oligo/poly(trimethylene carbonate)s were measured. Using 3-(4,5 dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide (MTT) assay, the star oligo/poly(trimethylene carbonate) was proved to have a low cytotoxicity. A microsphere drug-delivery system based on a star polymer was fabricated and its in vitro drug release property was studied.

Synthesis and properties of star oligo/poly(trimethylene carbonate)s with cholic acid moieties as cores.

We investigated in situ the effects of monomer structures on the formation and evolution of liquid-crystal texture and crystallization during thin-film polymerization of a series of liquid-crystalline and crystalline polymers. The monomers used in this study consisted of 2,6-acetoxynaphthoic acid (ANA), p-acetoxybenzoic acid (ABA), acetoxy acetanilide (AAA), and isophthalic acid (IA). The polycondensation reactions were conducted on the heating stage of a polarizing microscope. The formation of liquid crystallinity was found to be strongly dependent on the straight-monomer structures of ANA and ABA and their percentages as well as the reaction temperature. For the ANA/AAA/IA and ABA/AAA/IA reaction systems, the critical straight-monomer content (ANA or ABA) existed to form the liquid-crystalline (LC) state. Interestingly, the critical content to form liquid crystallinity decreased with an increase in the reaction temperature. Above the critical content, the appearance of a defective LC phase and the annihilation of disclinations were observed during the polycondensation reactions. The number of defects decreased with increasing reaction time through annihilation. The annihilation rate increased whereas the defect density decreased with increasing straight-monomer content. For the same molar ratio, the reaction system containing ANA had a faster annihilation rate than that containing ABA. Below the critical content, crystalline polymers were formed. Nucleation and crystal growth were observed during the reactions, and the rate of crystal growth decreased with increasing ANA or ABA content. For the systems having the same molar ratio of ANA or ABA, the ANA/AAA/IA system had a higher tendency to yield the LC phase than the ABA/ AAA/IA system because ANA has a longer mesogenic unit.

Effects of monomer structures on the evolution of liquid–crystal texture and crystallization during thin-film polymerization

A prodrug nanoassembly entrapping drugs as a tumor-targeted delivery system

A facile strategy for the fabrication of multi-functional polymer/inorganic hybrid nanoparticles for efficient gene and drug co-delivery was developed. A therapeutic gene (p53 plasmid) and a chemotherapy drug (doxorubicin hydrochloride, DOX) were co-loaded simultaneously in hybrid nanoparticles during co-precipitation with high encapsulation efficiency. The prepared heparin–biotin/heparin/CaCO3/calcium phosphate/DNA/DOX (HPB/HP/CaCO3/CaP/DNA/DOX) nanoparticles exhibited pH sensitivity and tumor-targeting property due to the presence of the CaCO3/CaP inorganic component and biotin moiety in the polymer chain, respectively. For comparison, HPB/HP/CaCO3/CaP/DOX hybrid nanoparticles for drug delivery were also fabricated. The cell inhibition effects of different nanoparticles on HeLa cells were evaluated using methylthiazole tetrazolium assay. In vitro study indicated that the gene and drug co-delivery system (HPB/HP/CaCO3/CaP/DNA/DOX) showed a stronger cell growth inhibition effect as compared with the drug delivery system (HPB/HP/CaCO3/CaP/DOX), indicating that HPB/HP/CaCO3/CaP/DNA/DOX hybrid nanoparticles could effectively mediate gene transfection and deliver the drug. The hybrid nanoparticles with good biocompatibility have great promise for gene and drug co-delivery. © 2014 Society of Chemical Industry

Multi-functional heparin–biotin/heparin/calcium carbonate/calcium phosphate nanoparticles for targeted co-delivery of gene and drug

https://onlinelibrary.wiley.com/doi/pdf/10.1002/adma.201970119

Si-Xue Cheng

Papers

Synthesis and properties of star oligo/poly(trimethylene carbonate)s with cholic acid moieties as cores.

Effects of monomer structures on the evolution of liquid–crystal texture and crystallization during thin-film polymerization

A prodrug nanoassembly entrapping drugs as a tumor-targeted delivery system

Multi-functional heparin–biotin/heparin/calcium carbonate/calcium phosphate nanoparticles for targeted co-delivery of gene and drug

Biomedical Materials: Engineered Bacterial Bioreactor for Tumor Therapy via Fenton-Like Reaction with Localized H2O2 Generation (Adv. Mater. 16/2019)