[신간의 별자리x] 우리/미술, 그리고 ‘슬픔의 박물관’

https://cyberleninka.org/article/n/933162.pdf

Hydrogels in drug delivery: progress and challenges

Molecular self-assembly is the spontaneous association of molecules under equilibrium conditions into stable, structurally well-defined aggregates joined by noncovalent bonds. Molecular self-assembly is ubiquitous in biological systems and underlies the formation of a wide variety of complex biological structures. Understanding self-assembly and the associated noncovalent interactions that connect complementary interacting molecular surfaces in biological aggregates is a central concern in structural biochemistry. Self-assembly is also emerging as a new strategy in chemical synthesis, with the potential of generating nonbiological structures with dimensions of 1 to 10(2) nanometers (with molecular weights of 10(4) to 10(10) daltons). Structures in the upper part of this range of sizes are presently inaccessible through chemical synthesis, and the ability to prepare them would open a route to structures comparable in size (and perhaps complementary in function) to those that can be prepared by microlithography and other techniques of microfabrication.

Molecular self-assembly and nanochemistry: A chemical strategy for the synthesis of nanostructures

https://www.farm.ucl.ac.be/Full-texts-FARM/Danhier-2010-2.pdf

To exploit the tumor microenvironment: Passive and active tumor targeting of nanocarriers for anti-cancer drug delivery

/pdf/degradable-controlled-release-polymers-and-polymeric-1y322ha58z.pdf

Degradable Controlled-Release Polymers and Polymeric Nanoparticles: Mechanisms of Controlling Drug Release

We prepared Ca-P/DNA co-precipitates deposited and encapsulated in polymer films for substrate-mediated gene delivery. The polymer films were composed of fast-degrading functionalized star poly(DL-lactide) CA-PDLLA and block copolymer poly(L-lactide)-poly(ethylene glycol)-poly(L-lactide) (PLLA-PEG-PLLA). The in vitrogene transfections of pGL3-Luc and pEGFP-C1 plasmids in HEK293T cells mediated by different films were studied. The effect of presence of a water-soluble polymer, poly-α,β-[N-(2-hydroxyethyl)-L-aspartamide], on the transfection activity of the film-mediated transfection was studied. The gene expressions could be effectively mediated by the Ca-P/DNA co-precipitates deposited and encapsulated in polymer films. During the cellular transfection, the fast-degrading films rapidly released Ca-P/DNA co-precipitates to mediate gene transfection, and the degradation products did not show any negative effects on the gene expression. The Ca-P/DNA co-precipitates deposited and encapsulated in films have promising applications in substrate-mediated gene delivery.

Three-dimensional fast-degrading polymer films for delivery of calcium phosphate/DNA co-precipitates in solid-phase transfection

Herein, a pH and redox dual-sensitive core-crosslinked targeting nanocarrier was prepared and used for co-delivery of doxorubicin (DOX) and tariquidar (TQR). The nanocarrier not only had excellent stability but also prevented the leakage of the drug in the normal physiological environment efficiently. Meanwhile, the targeting function of nanocarriers could also be suppressed in the normal physiological environment, protecting nanocarriers from being captured by RAW264.7 cells. Under mild acidic conditions, the targeting function was regained, leading to an effective tumor cell uptake of the nanocarrier. Furthermore, reduction-responsive drug release would occur in the cytoplasm due to the collapse of the reduction-sensitive crosslinked structure in the nanocarrier. By means of ligand-receptor mediated endocytosis and TQR-mediated glycoprotein (P-gp) inhibition, the IC50 value of DOX to MCF-7/ADR cells reduced from more than 100 μg mL-1 to 8.55 μg mL-1, exhibiting great potential in overcoming drug resistance.

Reversible core-crosslinked nanocarriers with pH-modulated targeting and redox-controlled drug release for overcoming drug resistance

The random copolymers of e-caprolactone (CL) and 2,2-ethylenedioxy propane-1,3-diol carbonate (EOPDC) were synthesized in bulk at 120 °C using Sn(Oct)2 as a catalyst. The poly(EOPDC-co–CL)s obtained were characterized by FT IR, 1H NMR, 13C NMR, GPC and DSC. The copolymers were obtained with yield of 84.2–97.8 %. The number-average molecular weight of the copolymer is 2.75–7.76 × 104 with a polydispersity of 1.52–1.68. The properties of the copolymer including the enzymatic degradation by Pseudomonas Cepacia lipase and drug-controlled release property were also investigated. The results showed that the copolymers are degradable at physiological conditions, and their degradation rate and release of Tegafur in the copolymers increase with increasing CL content in the copolymers.

Syntheses and properties of novel copolymers of polycaprolactone and aliphatic polycarbonate based on ketal-protected dihydroxyacetone

Intervening Tumor Progression by Coupling Bacteria Respiration with Tumor Metabolism

A series of biodegradable amphiphilic graft copolymers with poly-alpha,beta-[N-(2-hydroxyethyl)-L-aspartamide] (PHEA) as the backbone and poly(2,2-dimethyltrimethylene carbonate) (PDTC) segments with different lengths as the grafted branches were synthesized and characterized. The in vitro degradation of the obtained PHEA-g-PDTC copolymers was studied. With particular branch lengths, PHEA-g-PDTC can form self-assembling micelles in an aqueous solution. Transmission electron microscopy (TEM) images demonstrated that the micelles were regularly spherical in shape. The particle size and distribution of the micelles were measured. Nanoparticle drug delivery systems were prepared by the direct dissolution method. The in vitro release behaviors of two drugs, prednisone acetate and tegafur, with different water solubilities were investigated.

Si-Xue Cheng

Papers

Three-dimensional fast-degrading polymer films for delivery of calcium phosphate/DNA co-precipitates in solid-phase transfection

Reversible core-crosslinked nanocarriers with pH-modulated targeting and redox-controlled drug release for overcoming drug resistance

Syntheses and properties of novel copolymers of polycaprolactone and aliphatic polycarbonate based on ketal-protected dihydroxyacetone

Intervening Tumor Progression by Coupling Bacteria Respiration with Tumor Metabolism

Degradation and drug release properties of poly- α , β -[ N -(2-hydroxyethyl)- l -aspartamide]- g -poly(2,2-dimethyltrimethylene carbonate)