Si-Xue Cheng

TL;DR: Results indicate that this strategy for VDA-induced aggregation of gold nanoparticles to further destroy tumor vascular by photothermal effect has great potential in tumor treatment and could effectively enhance tumor vascular damage and avoid the side effects caused by frequent administration.

TL;DR: It was found that micelles loaded with prednisone acetate showed improved drug release behavior due to the special micellar structure and cytotoxicity study showed that the PCL-g-P(NIPAAm-co-HEMA) copolymer exhibits good biocompatibility.

TL;DR: In vitro release behavior of MTX was investigated, which showed a drastic thermoresponsive fast/slow switching behavior according to the temperature-responsive structural changes of a micellar shell structure.

TL;DR: Proteins have been extensively explored as versatile nanocarriers for drug delivery due to their complete biocompatibility, ease of surface modification, and lack of toxicity and immunogenicity, and aptamer-modified nanoparticles exhibit a significantly improved capability in up-regulating p16, p21 and E-cadherin, and down- Regulating EpCAM, vimentin, Snail, MMP-9, CD44 and CD133.

TL;DR: The strategy demonstrated in this study can be developed as a convenient approach for different types of short peptides to coassemble into a supramolecular hydrogel with multiple functions for the biomedical applications.