S
Siavash Fazel Darbandi
Researcher at University of California, San Francisco
Publications - 15
Citations - 1349
Siavash Fazel Darbandi is an academic researcher from University of California, San Francisco. The author has contributed to research in topics: Synaptogenesis & Biology. The author has an hindex of 7, co-authored 12 publications receiving 668 citations. Previous affiliations of Siavash Fazel Darbandi include University of Winnipeg.
Papers
More filters
Journal ArticleDOI
Predicting Splicing from Primary Sequence with Deep Learning.
Kishore Jaganathan,Sofia Kyriazopoulou Panagiotopoulou,Jeremy F. McRae,Siavash Fazel Darbandi,David A. Knowles,Yang I. Li,Jack A. Kosmicki,Jack A. Kosmicki,Juan Arbelaez,Wenwu Cui,Grace Schwartz,Eric D. Chow,Efstathios Kanterakis,Hong Gao,Amirali Kia,Serafim Batzoglou,Stephen Sanders,Kyle Kai-How Farh +17 more
TL;DR: A deep neural network is described that accurately predicts splice junctions from an arbitrary pre-mRNA transcript sequence, enabling precise prediction of noncoding genetic variants that cause cryptic splicing.
Journal ArticleDOI
Neonatal Tbr1 Dosage Controls Cortical Layer 6 Connectivity
Siavash Fazel Darbandi,Sarah E. Robinson Schwartz,Qihao Qi,Rinaldo Catta-Preta,Emily Ling-Lin Pai,Jeffrey D. Mandell,Amanda Everitt,Anna N. Rubin,Rebecca A. Krasnoff,Sol Katzman,David Tastad,Alexander Nord,A. Jeremy Willsey,Bin Chen,Matthew W. State,Vikaas S. Sohal,John L.R. Rubenstein +16 more
TL;DR: Conditional Tbr1 deletion during late mouse gestation in cortical layer 6 neurons (Tbr1layer6 mutants) provides novel insights into its function, including dendritic patterning, synaptogenesis, and cell-intrinsic physiology, and several putative TBR1 targets are ASD risk genes.
Journal ArticleDOI
TBR1 regulates autism risk genes in the developing neocortex.
James H. Notwell,Whitney E. Heavner,Siavash Fazel Darbandi,Sol Katzman,William L. McKenna,Christian F. Ortiz-Londono,David Tastad,Matthew J. Eckler,John L.R. Rubenstein,Susan K. McConnell,Bin Chen,Gill Bejerano +11 more
TL;DR: A TBR1-regulated network of ASD genes in the developing neocortex that are relatively intolerant to LoF mutations is highlighted, indicating that these genes may play critical roles in normal cortical development.
Journal ArticleDOI
Mafb and c-Maf Have Prenatal Compensatory and Postnatal Antagonistic Roles in Cortical Interneuron Fate and Function.
Emily Ling-Lin Pai,Daniel Vogt,Daniel Vogt,Alexandra Clemente-Perez,Gabriel L. McKinsey,Frances S. Cho,Jia Sheng Hu,Matt Wimer,Anirban Paul,Siavash Fazel Darbandi,Ramón Pla,Tomasz J. Nowakowski,Lisa V. Goodrich,Jeanne T. Paz,John L.R. Rubenstein +14 more
TL;DR: Mafb and c-Maf have distinct roles in postnatal cortical interneuron (CIN) morphological maturation, synaptogenesis, and cortical circuit integration, and they repress the generation of SST+ cortical and hippocampal interneurons.
Journal ArticleDOI
A comparative study of ryanodine receptor (RyR) gene expression levels in a basal ray-finned fish, bichir (Polypterus ornatipinnis) and the derived euteleost zebrafish (Danio rerio)
TL;DR: A survey of the genome of bichir (Polypterus ornatipinnis), considered the most basal ray-finned fish, for its RyR genes is reported, which shows fibre type-specific expression of the RyR1a andRyR1b genes.