Hong Gao

TL;DR: A deep neural network is described that accurately predicts splice junctions from an arbitrary pre-mRNA transcript sequence, enabling precise prediction of noncoding genetic variants that cause cryptic splicing.

TL;DR: Data show that cattle have undergone a rapid recent decrease in effective population size from a very large ancestral population, possibly due to bottlenecks associated with domestication, selection, and breed formation.

TL;DR: The popular Bayesian clustering approach STRUCTURES is extended for simultaneous inference of inbreeding or selfing rates and population-of-origin classification using multilocus genetic markers and it is shown that selfing leads to spurious signals of population substructure using the standard STRUCTURE algorithm with a bias toward spurious signal of admixture.

TL;DR: It is demonstrated that common missense variants in other primate species are largely clinically benign in human, enabling pathogenic mutations to be systematically identified by the process of elimination.

TL;DR: Five ways are outlined below ways in which scientists must integrate existing disciplinary evidence into rigorous models and must develop measures and methods to evaluate the multidimensional performance of FVCs.