A
Alexander Nord
Researcher at University of California, Davis
Publications - 82
Citations - 8858
Alexander Nord is an academic researcher from University of California, Davis. The author has contributed to research in topics: Enhancer & Gene. The author has an hindex of 40, co-authored 77 publications receiving 7706 citations. Previous affiliations of Alexander Nord include University of California, San Francisco & University of Washington.
Papers
More filters
Journal ArticleDOI
Rare Structural Variants Disrupt Multiple Genes in Neurodevelopmental Pathways in Schizophrenia
Tom Walsh,Jon McClellan,Shane McCarthy,Anjené M. Addington,Sarah B. Pierce,Greg M. Cooper,Alexander Nord,Mary Kusenda,Mary Kusenda,Dheeraj Malhotra,Abhishek Bhandari,Sunday M. Stray,Caitlin Rippey,Patricia Roccanova,Vlad Makarov,B. Lakshmi,Robert L. Findling,Linmarie Sikich,Linmarie Sikich,Thomas Stromberg,Barry Merriman,Nitin Gogtay,Philip Butler,Kristen L. Eckstrand,Laila Noory,Peter Gochman,Robert Long,Zugen Chen,Sean Davis,Carl Baker,Evan E. Eichler,Paul S. Meltzer,Stanley F. Nelson,Andrew B. Singleton,Ming K. Lee,Judith L. Rapoport,Mary Claire King,Jonathan Sebat +37 more
TL;DR: The results suggest that multiple, individually rare mutations altering genes in neurodevelopmental pathways contribute to schizophrenia, and disrupted genes disproportionately from signaling networks controlling neurodevelopment, including neuregulin and glutamate pathways.
Journal ArticleDOI
Mutations in 12 genes for inherited ovarian, fallopian tube, and peritoneal carcinoma identified by massively parallel sequencing
Tom Walsh,Silvia Casadei,Ming K. Lee,C. Pennil,Alexander Nord,Anne M. Thornton,Wendy Roeb,Kathy Agnew,Sunday M. Stray,Anneka Wickramanayake,Barbara M. Norquist,Kathryn P. Pennington,Rochelle L. Garcia,Mary Claire King,Elizabeth M. Swisher +14 more
TL;DR: Using targeted capture and massively parallel genomic sequencing, this paper screened for germ-line mutations in 21 tumor suppressor genes in genomic DNA from women with primary ovarian, peritoneal, or fallopian tube carcinoma.
Journal ArticleDOI
Germline and Somatic Mutations in Homologous Recombination Genes Predict Platinum Response and Survival in Ovarian, Fallopian Tube, and Peritoneal Carcinomas
Kathryn P. Pennington,Tom Walsh,Maria I. Harrell,Ming K. Lee,C. Pennil,Mara H. Rendi,Anne M. Thornton,Barbara M. Norquist,Silvia Casadei,Alexander Nord,Kathy Agnew,Colin C. Pritchard,Sheena M. Scroggins,Rochelle L. Garcia,Mary Claire King,Elizabeth M. Swisher +15 more
TL;DR: Germline or somatic mutations in homologous recombination genes are present in almost one third of ovarian carcinomas, including both serous and nonserous histologies, and the similar rate of homology recombination mutations in nonserous carcinomas supports their inclusion in PARP inhibitor clinical trials.
Journal ArticleDOI
Detection of inherited mutations for breast and ovarian cancer using genomic capture and massively parallel sequencing
Tom Walsh,Ming K. Lee,Silvia Casadei,Anne M. Thornton,Sunday M. Stray,C. Pennil,Alexander Nord,Jessica B. Mandell,Elizabeth M. Swisher,Mary Claire King +9 more
TL;DR: A genomic assay to capture, sequence, and detect all mutations in 21 genes, including BRCA1 and BRCa2, with inherited mutations that predispose to breast or ovarian cancer, which enables widespread genetic testing and personalized risk assessment for breast and ovarian cancer.
Journal ArticleDOI
Rapid and Pervasive Changes in Genome-wide Enhancer Usage during Mammalian Development
Alexander Nord,Matthew J. Blow,Matthew J. Blow,Catia Attanasio,Jennifer A. Akiyama,Amy Holt,Roya Hosseini,Sengthavy Phouanenavong,Ingrid Plajzer-Frick,Malak Shoukry,Veena Afzal,John L.R. Rubenstein,Edward M. Rubin,Edward M. Rubin,Len A. Pennacchio,Len A. Pennacchio,Axel Visel,Axel Visel,Axel Visel +18 more
TL;DR: The dynamic enhancer activities uncovered in this study illuminate rapid and pervasive temporal in vivo changes in enhancer usage that underlie processes central to development and disease.