S
Sibylle Cocciardi
Publications - 13
Citations - 540
Sibylle Cocciardi is an academic researcher. The author has contributed to research in topics: Myeloid leukemia & Leukemia. The author has an hindex of 7, co-authored 13 publications receiving 369 citations.
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Journal ArticleDOI
BCAT1 restricts αKG levels in AML stem cells leading to IDHmut-like DNA hypermethylation
Simon Raffel,Mattia Falcone,Niclas Kneisel,Jenny Hansson,Wei Wang,Christoph Lutz,Lars Bullinger,Gernot Poschet,Yannic Nonnenmacher,Andrea Barnert,Carsten Bahr,Petra Zeisberger,Adriana Przybylla,Markus Sohn,Martje Tönjes,Ayelet Erez,Lital Adler,Patrizia Jensen,Claudia Scholl,Stefan Fröhling,Stefan Fröhling,Sibylle Cocciardi,Patrick Wuchter,Christian Thiede,Anne Flörcken,Jörg Westermann,Gerhard Ehninger,Peter Lichter,Karsten Hiller,Karsten Hiller,Rüdiger Hell,Carl Herrmann,Anthony D. Ho,Jeroen Krijgsveld,Bernhard Radlwimmer,Andreas Trumpp +35 more
TL;DR: The results suggest the BCAA–BCAT1–αKG pathway as a therapeutic target to compromise leukaemia stem-cell function in patients with IDHWTTET2WT AML.
Journal ArticleDOI
Clonal evolution patterns in acute myeloid leukemia with NPM1 mutation
Sibylle Cocciardi,Anna Dolnik,Silke Kapp-Schwoerer,Frank G. Rücker,Susanne Lux,Tamara J. Blätte,Sabrina Skambraks,Jan Krönke,Florian H. Heidel,Florian H. Heidel,Tina M. Schnöder,Tina M. Schnöder,Andrea Corbacioglu,Verena I. Gaidzik,Peter Paschka,Veronica Teleanu,Gudrun Göhring,Felicitas Thol,Michael Heuser,Arnold Ganser,Daniela Weber,Eric Sträng,Hans A. Kestler,Hartmut Döhner,Lars Bullinger,Konstanze Döhner +25 more
TL;DR: It is found that at relapse, some patients lose the NPM1 mutation and show distinct mutational and gene expression patterns, highlighting a potential route for relapse.
Journal ArticleDOI
Circular RNAs of the nucleophosmin (NPM1) gene in acute myeloid leukemia.
Susanne Hirsch,Tamara J. Blätte,Sarah Grasedieck,Sibylle Cocciardi,Arefeh Rouhi,Mojca Jongen-Lavrencic,Peter Paschka,Jan Krönke,Verena I. Gaidzik,Hartmut Döhner,Richard F. Schlenk,Florian Kuchenbauer,Konstanze Döhner,Anna Dolnik,Lars Bullinger +14 more
TL;DR: While circRNA expression correlates globally with parental gene expression, hematopoietic differentiation-associated as well as acute myeloid leukemia subgroup-specific circRNA signatures are identified.
Journal ArticleDOI
Altered miRNA and gene expression in acute myeloid leukemia with complex karyotype identify networks of prognostic relevance
F.G. Rücker,Annika C. Russ,Sibylle Cocciardi,Helena Kett,Richard F. Schlenk,Ursula Botzenhardt,Christian Langer,Jürgen Krauter,Stefan Frohling,Brigitte Schlegelberger,Arnold Ganser,Peter Lichter,Thorsten Zenz,Thorsten Zenz,Hartmut Döhner,K Döhner,Lars Bullinger +16 more
TL;DR: Detailed molecular profiling links impaired p53 to decreased miR-34a expression, but also identifies p53-independent miR -34a induction mechanisms as shown in TP53biallelic altered cell lines treated with 15-deoxy-Δ12,14-prostaglandin.
Journal ArticleDOI
getITD for FLT3-ITD-based MRD monitoring in AML
Tamara J. Blätte,Laura K. Schmalbrock,Sabrina Skambraks,Susanne Lux,Sibylle Cocciardi,Anna Dolnik,Hartmut Döhner,Konstanze Döhner,Lars Bullinger +8 more
TL;DR: Idelalisib improves CD37 antibody BI 836826 cytotoxicity against chemo-resistant/relapse-initiating CLL cells: a rationale for combination treatment in combination with chemotherapeutic agents or PI3K inhibitors.