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Yannic Nonnenmacher
Researcher at Braunschweig University of Technology
Publications - 18
Citations - 1005
Yannic Nonnenmacher is an academic researcher from Braunschweig University of Technology. The author has contributed to research in topics: Citric acid cycle & Mitochondrion. The author has an hindex of 11, co-authored 16 publications receiving 664 citations. Previous affiliations of Yannic Nonnenmacher include University of Luxembourg & Saarland University.
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Journal ArticleDOI
Glutathione Primes T Cell Metabolism for Inflammation
Tak W. Mak,Tak W. Mak,Melanie Grusdat,Gordon S. Duncan,Catherine Dostert,Yannic Nonnenmacher,Yannic Nonnenmacher,Maureen A. Cox,Carole Binsfeld,Zhenyue Hao,Zhenyue Hao,Anne Brüstle,Momoe Itsumi,Christian Jäger,Ying Chen,Olaf Pinkenburg,Bärbel Camara,Markus Ollert,Carsten Bindslev-Jensen,Vasilis Vasiliou,Chiara Gorrini,Philipp A. Lang,Michael Lohoff,Isaac S. Harris,Karsten Hiller,Karsten Hiller,Dirk Brenner +26 more
TL;DR: It is reported that GSH is essential for T cell effector functions through its regulation of metabolic activity and plays an unexpected role in metabolic integration and reprogramming during inflammatory T cell responses.
Journal ArticleDOI
BCAT1 restricts αKG levels in AML stem cells leading to IDHmut-like DNA hypermethylation
Simon Raffel,Mattia Falcone,Niclas Kneisel,Jenny Hansson,Wei Wang,Christoph Lutz,Lars Bullinger,Gernot Poschet,Yannic Nonnenmacher,Andrea Barnert,Carsten Bahr,Petra Zeisberger,Adriana Przybylla,Markus Sohn,Martje Tönjes,Ayelet Erez,Lital Adler,Patrizia Jensen,Claudia Scholl,Stefan Fröhling,Stefan Fröhling,Sibylle Cocciardi,Patrick Wuchter,Christian Thiede,Anne Flörcken,Jörg Westermann,Gerhard Ehninger,Peter Lichter,Karsten Hiller,Karsten Hiller,Rüdiger Hell,Carl Herrmann,Anthony D. Ho,Jeroen Krijgsveld,Bernhard Radlwimmer,Andreas Trumpp +35 more
TL;DR: The results suggest the BCAA–BCAT1–αKG pathway as a therapeutic target to compromise leukaemia stem-cell function in patients with IDHWTTET2WT AML.
Journal ArticleDOI
Glutathione Restricts Serine Metabolism to Preserve Regulatory T Cell Function.
Henry Kurniawan,Davide G. Franchina,Luana Guerra,Lynn Bonetti,Leticia Soriano Baguet,Melanie Grusdat,Lisa Schlicker,Oliver Hunewald,Catherine Dostert,Myriam P. Merz,Carole Binsfeld,Gordon S. Duncan,Sophie Farinelle,Yannic Nonnenmacher,Jillian Haight,Dennis Das Gupta,Anouk Ewen,Rabia Taskesen,Rashi Halder,Ying Chen,Christian Jäger,Markus Ollert,Paul Wilmes,Vasilis Vasiliou,Isaac S. Harris,Christiane B. Knobbe-Thomsen,Jonathan D. Turner,Tak W. Mak,Tak W. Mak,Tak W. Mak,Michael Lohoff,Johannes Meiser,Karsten Hiller,Dirk Brenner,Dirk Brenner +34 more
TL;DR: An unexpected role for GSH in restricting serine availability to preserve Treg functionality is revealed, using mice with Treg-specific ablation of the catalytic subunit of glutamate cysteine ligase.
Journal ArticleDOI
Biochemistry of proinflammatory macrophage activation
TL;DR: This review will aim to provide an overview of the metabolic responses during proinflammatory macrophage activation and show how these changes modulate the immune response.
Journal ArticleDOI
Oncogenic IDH1 Mutations Promote Enhanced Proline Synthesis through PYCR1 to Support the Maintenance of Mitochondrial Redox Homeostasis
Kate E.R. Hollinshead,Haydn Munford,Katherine L. Eales,Chiara Bardella,Chiara Bardella,Chunjie Li,Cristina Escribano-Gonzalez,Alpesh Thakker,Yannic Nonnenmacher,Katarina Kluckova,Mark Jeeves,Robert Murren,Federica Cuozzo,Dan Ye,Giulio Laurenti,Wei Zhu,Karsten Hiller,David J. Hodson,Wei Hua,Ian Tomlinson,Christian Ludwig,Ying Mao,Daniel A. Tennant +22 more
TL;DR: A mechanism by which tumor cell survival may be promoted in conditions associated with perturbed redox homeostasis, as occurs in IDH1-mutated glioma is uncovered.