Wei Wang

TL;DR: It is shown that reduced H3K27me3 levels and DNA hypomethylation act in concert to activate gene expression in K27M mutant pHGGs, and it is demonstrated that this is caused by aberrant recruitment of the PRC2 complex to K 27M mutant H3.3.

TL;DR: GFI1 and GFI1B are identified as prominent medulloblastoma oncogenes and ‘enhancer hijacking’ is implicate as an efficient mechanism driving oncogene activation in a childhood cancer.

TL;DR: A derivatized porphyrin with long alkyl chains, 5,10,15,20-tetrakis(hexadecyloxyphenyl)-21H,23H-porphine, is selective toward semiconducting single-walled carbon nanotubes (SWNTs) in presumably noncovalent interactions, resulting in significantly enriched semiconductor SWNTs in the solubilized sample.

TL;DR: This comprehensive data set allowed us to decipher several features underlying the interplay between the genome, epigenome and transcriptome, and its effects on medulloblastoma pathophysiology, including highly prevalent regions of hypomethylation correlating with increased gene expression and focal regions of low methylation linked to transcription-factor-binding sites shed light on differential transcriptional networks between subgroups.

TL;DR: A central role for BCAT1 in glioma pathogenesis is suggested, makingBCAT1 and BCAA metabolism attractive targets for the development of targeted therapeutic approaches to treat patients with glioblastoma.