S
Sihan Li
Researcher at Tohoku University
Publications - 5
Citations - 94
Sihan Li is an academic researcher from Tohoku University. The author has contributed to research in topics: Monoubiquitination & Ribosomal protein. The author has an hindex of 3, co-authored 5 publications receiving 46 citations.
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Journal ArticleDOI
Sequential Ubiquitination of Ribosomal Protein uS3 Triggers the Degradation of Non-functional 18S rRNA
Takato Sugiyama,Sihan Li,Misaki Kato,Ken Ikeuchi,Atsushi Ichimura,Yoshitaka Matsuo,Toshifumi Inada +6 more
TL;DR: Determination of the aberrant 18S rRNA levels in sucrose gradient fractions revealed that the subunit dissociation of stalled ribosomes requires sequential ubiquitination of uS3 by E3 ligases and ATPase activity of Slh1 (Rqt2), as well as Asc1 and Dom34.
Journal ArticleDOI
Ribosomal protein S7 ubiquitination during ER stress in yeast is associated with selective mRNA translation and stress outcome.
Yasuko Matsuki,Yoshitaka Matsuo,Yu Nakano,Shintaro Iwasaki,Shintaro Iwasaki,Hideyuki Yoko,Tsuyoshi Udagawa,Sihan Li,Yasushi Saeki,Tohru Yoshihisa,Keiji Tanaka,Nicholas T. Ingolia,Toshifumi Inada +12 more
TL;DR: The findings suggest that the monoubiquitination of ribosomal protein eS7A plays a crucial role in translational controls during the ER stress response in yeast.
Journal ArticleDOI
Age-Dependent Ribosomal DNA Variations in Mice.
Eriko Watada,Sihan Li,Yutaro Hori,Katsunori Fujiki,Katsuhiko Shirahige,Toshifumi Inada,Takehiko Kobayashi +6 more
TL;DR: The findings suggest that rDNA is also fragile in mammalian cells and that alterations within this region have a profound effect on cellular function.
Posted ContentDOI
Age-dependent ribosomal DNA variations and their effect on cellular function in mammalian cells
Eriko Watada,Sihan Li,Yutaro Hori,Katsunori Fujiki,Katsuhiko Shirahige,Toshifumi Inada,Takehiko Kobayashi +6 more
TL;DR: It is shown that rDNA copy number increases in old mice bone marrow cells and the level of ribosomal RNA production was reduced because of increased levels of DNA methylation that represses transcription.
Posted ContentDOI
Ribosomal protein S7 ubiquitination during ER stress in yeast is associated with selective mRNA translation and stress outcome
Yasuko Matsuki,Yoshitaka Matsuo,Yu Nakano,Shintaro Iwasaki,Shintaro Iwasaki,Hideyuki Yoko,Tsuyoshi Udagawa,Sihan Li,Yasushi Saeki,Tohru Yoshihisa,Keiji Tanaka,Nicholas T. Ingolia,Toshifumi Inada +12 more
TL;DR: The findings suggest that the monoubiquitination of ribosomal protein eS7A plays a crucial role in translational controls during the ER stress response in yeast.