Sequential Ubiquitination of Ribosomal Protein uS3 Triggers the Degradation of Non-functional 18S rRNA
Takato Sugiyama,Sihan Li,Misaki Kato,Ken Ikeuchi,Atsushi Ichimura,Yoshitaka Matsuo,Toshifumi Inada +6 more
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TLDR
Determination of the aberrant 18S rRNA levels in sucrose gradient fractions revealed that the subunit dissociation of stalled ribosomes requires sequential ubiquitination of uS3 by E3 ligases and ATPase activity of Slh1 (Rqt2), as well as Asc1 and Dom34.About:
This article is published in Cell Reports.The article was published on 2019-03-19 and is currently open access. It has received 57 citations till now. The article focuses on the topics: Eukaryotic Ribosome & Ribosomal protein.read more
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Journal ArticleDOI
Quality controls induced by aberrant translation.
TL;DR: This review focuses on the mechanisms used by these quality control pathways to recognize aberrant ribosome stalling and discusses the conservation of these systems.
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The G3BP1-Family-USP10 Deubiquitinase Complex Rescues Ubiquitinated 40S Subunits of Ribosomes Stalled in Translation from Lysosomal Degradation.
TL;DR: It is shown that G3BP1-family-USP10 complexes are required for deubiquitination of RPS2, RPS3, and RPS10 to rescue modified 40S subunits from programmed degradation, and G3 BP1 family proteins have long been considered RNA-binding proteins, however, they are identified as their predominant targets.
Journal ArticleDOI
Ribosome Abundance Control Via the Ubiquitin-Proteasome System and Autophagy.
Heeseon An,J. Wade Harper +1 more
TL;DR: A review of mechanisms that regulate ribosome abundance through both the ubiquitin-proteasome system and forms of autophagy referred to as "ribophagy" can be found in this paper.
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The Impact of Oxidative Stress on Ribosomes: From Injury to Regulation
TL;DR: A concise summary of the known types of changes induced by reactive oxygen species in rRNA and ribosomal proteins is provided and the existing experimental evidence of how these modifications may affect ribosome dynamics and function is discussed.
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Oxidation and alkylation stresses activate ribosome-quality control.
TL;DR: No-go decay (NGD) and ribosome-quality control (RQC) pathways are activated by mRNAs damaged by alkylation and oxidation stress, highlighting the burden of chemically damaged mRNA on cellular homeostasis and suggesting that organisms evolved mechanisms to counter their accumulation.
References
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Mark S. Longtine,Amos Mckenzie,Douglas J. Demarini,Nirav Shah,Achim Wach,Arndt Brachat,Peter Philippsen,John R. Pringle +7 more
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Maya Schuldiner,Sean R. Collins,Natalie J. Thompson,Vladimir Denic,Arunashree Bhamidipati,Thanuja Punna,Jan Ihmels,Brenda J. Andrews,Charles Boone,Jack Greenblatt,Jonathan S. Weissman,Nevan J. Krogan +11 more
TL;DR: Analysis of an E-MAP of genes acting in the yeast early secretory pathway revealed or clarified the role of many proteins involved in extensively studied processes such as sphingolipid metabolism and retention of HDEL proteins.
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Endonucleolytic cleavage of eukaryotic mRNAs with stalls in translation elongation
Meenakshi K. Doma,Roy Parker +1 more
TL;DR: It is shown that yeast mRNAs with stalls in translation elongation are recognized and targeted for endonucleolytic cleavage, referred to as ‘no-go decay’, which provides a mechanism for clearing the cell of stalledtranslation elongation complexes.
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Regulation of cytoplasmic mRNA decay
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