S
Silvia C. Formenti
Researcher at Cornell University
Publications - 396
Citations - 32827
Silvia C. Formenti is an academic researcher from Cornell University. The author has contributed to research in topics: Radiation therapy & Breast cancer. The author has an hindex of 74, co-authored 372 publications receiving 25850 citations. Previous affiliations of Silvia C. Formenti include Catholic University of the Sacred Heart & New York University.
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Journal ArticleDOI
Anticancer immunotherapy by CTLA-4 blockade relies on the gut microbiota
Marie Vétizou,Marie Vétizou,Marie Vétizou,Jonathan M. Pitt,Jonathan M. Pitt,Jonathan M. Pitt,Romain Daillère,Romain Daillère,Romain Daillère,Patricia Lepage,Nadine Waldschmitt,Caroline Flament,Caroline Flament,Sylvie Rusakiewicz,Sylvie Rusakiewicz,Bertrand Routy,Maria Paula Roberti,Maria Paula Roberti,Connie P.M. Duong,Connie P.M. Duong,Vichnou Poirier-Colame,Vichnou Poirier-Colame,Antoine Roux,Antoine Roux,Antoine Roux,Sonia Becharef,Sonia Becharef,Silvia C. Formenti,Encouse B. Golden,Sascha Cording,Gérard Eberl,Andreas Schlitzer,Florent Ginhoux,Sridhar Mani,Takahiro Yamazaki,Takahiro Yamazaki,Nicolas Jacquelot,Nicolas Jacquelot,Nicolas Jacquelot,David Enot,David Enot,Marion Bérard,Jérôme Nigou,Jérôme Nigou,Paule Opolon,Alexander M.M. Eggermont,Alexander M.M. Eggermont,Paul Louis Woerther,Elisabeth Chachaty,Nathalie Chaput,Nathalie Chaput,Caroline Robert,Caroline Robert,Christina Mateus,Guido Kroemer,Didier Raoult,Ivo G. Boneca,Ivo G. Boneca,Franck Carbonnel,Mathias Chamaillard,Laurence Zitvogel +60 more
TL;DR: A key role is revealed for Bacteroidales in the immunostimulatory effects of CTLA-4 blockade, which is found to depend on distinct Bacteroides species in mice and patients.
Journal ArticleDOI
Fractionated but not single dose radiotherapy induces an immune-mediated abscopal effect when combined with anti-CTLA-4 antibody
M. Zahidunnabi Dewan,Ashley E. Galloway,Noriko Kawashima,J. Keith DeWyngaert,James S. Babb,Silvia C. Formenti,Sandra Demaria +6 more
TL;DR: Fractionated but not single-dose radiotherapy induces an abscopal effect when in combination with anti–CTLA-4 antibody in two preclinical carcinoma models.
Journal ArticleDOI
Ionizing radiation inhibition of distant untreated tumors (abscopal effect) is immune mediated
Sandra Demaria,Bruce Ng,M. Devitt,James S. Babb,Noriko Kawashima,Leonard Liebes,Silvia C. Formenti +6 more
TL;DR: The results demonstrate that the abscopal effect is in part immune mediated and that T cells are required to mediate distant tumor inhibition induced by radiation.
Journal ArticleDOI
DNA exonuclease Trex1 regulates radiotherapy-induced tumour immunogenicity.
Claire Vanpouille-Box,Amandine Alard,Amandine Alard,Molykutty J. Aryankalayil,Yasmeen Sarfraz,Julie M. Diamond,Robert J. Schneider,Giorgio Inghirami,C. Norman Coleman,Silvia C. Formenti,Sandra Demaria +10 more
TL;DR: It is shown that the DNA exonuclease Trex1 is induced by radiation doses above 12–18 Gy in different cancer cells, and attenuates their immunogenicity by degrading DNA that accumulates in the cytosol upon radiation.
Journal Article
Immune-mediated inhibition of metastases after treatment with local radiation and CTLA-4 blockade in a mouse model of breast cancer.
Sandra Demaria,Noriko Kawashima,Anne Marie Yang,M. Devitt,James S. Babb,James P. Allison,James P. Allison,Silvia C. Formenti +7 more
TL;DR: The combination of local RT with CTLA-4 blockade is a promising new immunotherapeutic strategy against poorly immunogenic metastatic cancers.