Simon C. Cork

TL;DR: Major sites of glp1r expression include pancreatic β- and δ-cells, vascular smooth muscle, cardiac atrium, gastric antrum/pylorus, enteric neurones, and vagal and dorsal root ganglia, which may contribute to intestinal and central responses to locally released GLP-1, such as regulation of intestinal secretomotor activity and appetite.

TL;DR: The power of combining the novel GLP-1R-CRE mouse with a virus to generate a selective molecular handle enabling future in vivo investigation as to their physiological importance is demonstrated.

TL;DR: The design and development of a photoswitchable sulfonylurea, JB253, is described, which reversibly and repeatedly blocks KATP channel activity following exposure to violet-blue light, enabling the optical control of insulin release and may offer a valuable research tool for the interrogation of KatP channel function in health and T2DM.

TL;DR: Findings indicate that satiation is a main driver of PPG neuronal activation and show that PPG neurons are in a prime position to respond to both immediate and long-term indicators of energy and feeding status, enabling regulation of both energy balance and general autonomic homeostasis.

TL;DR: The hypothesis that purinergic signaling plays a significant role in generation of BOLD fMRI signals is tested and it is hypothesized that astrocytes activated during periods of enhanced neuronal activity release ATP, which propagatesAstrocytic activation, stimulates release of vasoactive substances and dilation of cerebral vasculature.