S
Simon G. Gregory
Researcher at Duke University
Publications - 216
Citations - 50384
Simon G. Gregory is an academic researcher from Duke University. The author has contributed to research in topics: Single-nucleotide polymorphism & Gene. The author has an hindex of 54, co-authored 198 publications receiving 47130 citations. Previous affiliations of Simon G. Gregory include University of Helsinki & Wellcome Trust.
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Journal ArticleDOI
Genetic effects in the leukotriene biosynthesis pathway and association with atherosclerosis.
David R. Crosslin,Svati H. Shah,Sarah C. Nelson,Carol Haynes,Jessica J. Connelly,Shera Gadson,Pascal J. Goldschmidt-Clermont,Jeffery M. Vance,Jason J. Rose,Christopher B. Granger,David Seo,Simon G. Gregory,William E. Kraus,Elizabeth R. Hauser +13 more
TL;DR: A modest role for the leukotriene pathway in Atherosclerosis pathogenesis is supported, important genomic interactions within the pathway are revealed, and the importance of using pathway-based modeling for evaluating the genomics of atherosclerosis susceptibility is suggested.
Journal ArticleDOI
Tiling path resolution mapping of constitutional 1p36 deletions by array-CGH: contiguous gene deletion or “deletion with positional effect” syndrome?
Richard Redon,Marlène Rio,Simon G. Gregory,R. A. Cooper,Heike Fiegler,Damien Sanlaville,Ruby Banerjee,Carol Scott,P Carr,Cordelia Langford,Valérie Cormier-Daire,Arnold Munnich,Nigel P. Carter,Laurence Colleaux +13 more
TL;DR: Refin- ing the sizes of the deletions in affected individuals, in conjunction with phenotype/genotype correlation, will aid in identifying candidate genes within critical deletion intervals, according to Wu et al.
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Whole Genomic Copy Number Alterations in Circulating Tumor Cells from Men with Abiraterone or Enzalutamide-Resistant Metastatic Castration-Resistant Prostate Cancer.
Santosh Gupta,Jing Li,Gabor Kemeny,Rhonda L. Bitting,Joshua Beaver,Jason A. Somarelli,Kathryn E. Ware,Simon G. Gregory,Andrew J. Armstrong +8 more
TL;DR: Genomic analysis of pooled CTCs in men with mCRPC suggests a reproducible, but highly complex molecular profile that includes common aberrations in AR, ERG, c-MET, and PI3K signaling during m CRPC progression, which may be useful for predictive biomarker development.
Journal ArticleDOI
Report of the fifth international workshop on human chromosome 1 mapping 1999.
Peter White,A. Forus,Tara C. Matise,B. C. Schutte,N. Spieker,P. Stanier,Jeffery M. Vance,Simon G. Gregory +7 more
Journal ArticleDOI
Evidence for fumonisin inhibition of ceramide synthase in humans consuming maize-based foods and living in high exposure communities in Guatemala
Ronald T. Riley,Olga Torres,Jorge Matute,Simon G. Gregory,Allison E. Ashley-Koch,Jency L. Showker,Trevor R. Mitchell,Kenneth A. Voss,Joyce R. Maddox,Janee Gelineau-van Waes +9 more
TL;DR: High levels of FB1 intake are correlated with changes in Sa 1-P and the Sa 1,P/So1-P ratio in human blood in a manner consistent with FB1 inhibition of CerS.