S
Simon G. Gregory
Researcher at Duke University
Publications - 216
Citations - 50384
Simon G. Gregory is an academic researcher from Duke University. The author has contributed to research in topics: Single-nucleotide polymorphism & Gene. The author has an hindex of 54, co-authored 198 publications receiving 47130 citations. Previous affiliations of Simon G. Gregory include University of Helsinki & Wellcome Trust.
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Journal ArticleDOI
SNPselector: a web tool for selecting SNPs for genetic association studies
Hong Xu,Simon G. Gregory,Elizabeth R. Hauser,Judith E. Stenger,Margaret A. Pericak-Vance,Jeffery M. Vance,Stephan Züchner,Michael A. Hauser +7 more
TL;DR: A web-based program, SNPselector, to automate the process of manually choosing thousands of genotyping SNPs for tens or hundreds of genes, and prioritizes these SNPs on their tagging for linkage disequilibrium, SNP allele frequencies and source, function, regulatory potential and repeat status.
Journal ArticleDOI
Erratum: The DNA sequence and biological annotation of human chromosome 1 (Nature (2006) 441 (315-321))
Simon G. Gregory,K F Barlow,Kirsten McLay,R Kaul,David Swarbreck,Andrew Dunham,Carol Scott,Kerstin Howe,K Woodfine,Spencer Cca.,Matthew Jones,Christopher J. Gillson,S. Searle,Y Zhou,Felix Kokocinski,L McDonald,R Evans,Katharine A. Phillips,A Atkinson,R Cooper,C Jones,Rebekah Hall,T D Andrews,Christine Lloyd,R Ainscough,J P Almeida,K D Ambrose,F Anderson,R. W. Andrew,Ashwell Ris.,K Aubin,A K Babbage,C L Bagguley,J Bailey,Ruby Banerjee,Helen Beasley,Graeme Bethel,Christine P. Bird,S Bray-Allen,J Y Brown,A J Brown,S P Bryant,D Buckley,D C Burford,Burrill Wdh.,John Burton,Jacqueline M. Bye,C Carder,J C Chapman,S Y Clark,G Clarke,C M Clee,S. M. Clegg,V. Cobley,R. E. Collier,N Corby,G. J. Coville,Joy Davies,Rebecca Deadman,Pawandeep Dhami,Oliver M. Dovey,Matthew Dunn,M Earthrowl,A. G. Ellington,H Errington,L M Faulkner,Adam Frankish,J Frankland,Lisa French,P Garner,J Garnett,Ghori Mrj.,Richard Gibson,L M Gilby,W Gillett,Rebecca Glithero,Darren Grafham,Susan M. Gribble,C Griffiths,Sam Griffiths-Jones,Russell J. Grocock,S Hammond,Harrison Esi.,E. Hart,E Haugen,Paul Heath,S. Holmes,Kathryn E. Holt,Philip Howden,Adrienne Hunt,Sarah E. Hunt,G Hunter,J Isherwood,R James,Chris Johnson,David H. Johnson,A Joy,M. Kay,J K Kershaw +98 more
TL;DR: This corrects the article to show that the method used to derive the H2O2 “spatially aggregating force” is based on a two-step process, not a single step, like in the previous version of this paper.
Journal ArticleDOI
Neuropeptide Y gene polymorphisms confer risk of early-onset atherosclerosis.
Svati H. Shah,Neil J. Freedman,Lisheng Zhang,David R. Crosslin,David H. Stone,Carol Haynes,Jessica S. Johnson,Sarah C. Nelson,Liyong Wang,Jessica J. Connelly,Michael J. Muehlbauer,Geoffrey S. Ginsburg,David C. Crossman,Christopher J. H. Jones,Jeffery M. Vance,Michael H. Sketch,Christopher B. Granger,Christopher B. Newgard,Simon G. Gregory,Pascal J. Goldschmidt-Clermont,William E. Kraus,Elizabeth R. Hauser +21 more
TL;DR: NPY variants associate with atherosclerosis in two independent datasets (with strong age-of-onset effects) and show allele-specific expression with NPY levels, while NPY receptor antagonism reduces atherosclerotic neointimal area in mice.
Journal ArticleDOI
Integrated genomic analyses identify ERRFI1 and TACC3 as glioblastoma-targeted genes
Christopher G. Duncan,Patrick J. Killela,Cathy A. Payne,Benjamin L. Lampson,William C. Chen,Jeff C. Liu,David A. Solomon,Todd Waldman,Aaron J. Towers,Simon G. Gregory,Kerrie L. McDonald,Roger E. McLendon,Darell D. Bigner,Hai-Jing Yan +13 more
TL;DR: A multifaceted genomic evaluation of glioblastoma establishes ERRFI1 as a potential candidate tumor suppressor gene and TACC3 as a possible oncogene, and provides insight on targets for oncogenic pathway-based therapy.
Journal ArticleDOI
GATA2 Is Associated with Familial Early-Onset Coronary Artery Disease
Jessica J. Connelly,Tianyuan Wang,Julie E Cox,Carol Haynes,Liyong Wang,Svati H. Shah,David R. Crosslin,A. Brent Hale,Sarah C. Nelson,David C. Crossman,Christopher B. Granger,Jonathan L. Haines,Christopher J. Jones,Jeffery M. Vance,Pascal J. Goldschmidt-Clermont,William E. Kraus,Elizabeth R. Hauser,Simon G. Gregory +17 more
TL;DR: Observations identify GATA2 as a novel susceptibility gene for coronary artery disease and suggest that the study of this transcription factor and its downstream targets may uncover a regulatory network important for coronary arteries disease inheritance.