S
Simon G. Gregory
Researcher at Duke University
Publications - 216
Citations - 50384
Simon G. Gregory is an academic researcher from Duke University. The author has contributed to research in topics: Single-nucleotide polymorphism & Gene. The author has an hindex of 54, co-authored 198 publications receiving 47130 citations. Previous affiliations of Simon G. Gregory include University of Helsinki & Wellcome Trust.
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Journal ArticleDOI
A second major histocompatibility complex susceptibility locus for multiple sclerosis
Tai Wai Yeo,Philip L. De Jager,Simon G. Gregory,Lisa F. Barcellos,Lisa F. Barcellos,Amie Walton,An Goris,Chiara Fenoglio,Chiara Fenoglio,Maria Ban,Craig J. Taylor,Reyna S. Goodman,Emily Walsh,Cara S Wolfish,Roger Horton,James A. Traherne,Stephan Beck,John Trowsdale,Stacy J. Caillier,Adrian J. Ivinson,Todd Green,Susan Pobywajlo,Eric S. Lander,Margaret A. Pericak-Vance,Jonathan L. Haines,Mark J. Daly,Jorge R. Oksenberg,Stephen L. Hauser,Alastair Compston,David A. Hafler,John D. Rioux,Stephen Sawcer +31 more
TL;DR: Variation in the major histocompatibility complex (MHC) on chromosome 6p21 is known to influence susceptibility to multiple sclerosis with the strongest effect originating from the HLA‐DRB1 gene in the class II region.
Journal ArticleDOI
Missense mutations in TCF8 cause late-onset Fuchs corneal dystrophy and interact with FCD4 on chromosome 9p.
S. Amer Riazuddin,Norann A. Zaghloul,Amr Al-Saif,Lisa Davey,Bill H. Diplas,Danielle N. Meadows,Allen O. Eghrari,Mollie A. Minear,Yi-Ju Li,Gordon K. Klintworth,Natalie A. Afshari,Simon G. Gregory,John D. Gottsch,Nicholas Katsanis,Nicholas Katsanis +14 more
TL;DR: The data suggest that PPCD and FCD are allelic variants of the same disease continuum and that genetic interaction between genes that cause corneal dystrophies can modulate the expressivity of the phenotype.
Journal ArticleDOI
Definition and characterization of a region of 1p36.3 consistently deleted in neuroblastoma.
Peter White,Peter White,Patricia M. Thompson,Takahiro Gotoh,Erin R. Okawa,Jun Igarashi,Marleen Kok,Cynthia Winter,Simon G. Gregory,Michael D. Hogarty,Michael D. Hogarty,John M. Maris,John M. Maris,Garrett M. Brodeur,Garrett M. Brodeur +14 more
TL;DR: Results suggest that one or more genes involved in neuroblastoma tumorigenesis or tumor progression are likely contained within this region of distal chromosome 1p.
Journal ArticleDOI
Erratum: Initial sequencing and analysis of the human genome: International Human Genome Sequencing Consortium (Nature (2001) 409 (860-921))
Eric S. Lander,Lauren Linton,Bruce W. Birren,Chad Nusbaum,Michael C. Zody,Jennifer Baldwin,Keri Devon,Ken Dewar,Michael Doyle,William Fitzhugh,Roel Funke,Diane Gage,Katrina Harris,Andrew Heaford,John Howland,Lisa Kann,Jessica A. Lehoczky,Rosie Levine,Paul A. McEwan,Kevin McKernan,James Meldrim,Jill P. Mesirov,Cher Miranda,William Morris,Jerome Naylor,Christina Raymond,Mark Rosetti,Ralph Santos,Andrew Sheridan,Carrie Sougnez,Nicole Stange-Thomann,Nikola Stojanovic,Aravind Subramanian,Dudley Wyman,Jane Rogers,John Sulston,R Ainscough,Stephan Beck,David R. Bentley,John Burton,C M Clee,Nigel P. Carter,A. Coulson,Rebecca Deadman,Panos Deloukas,Andrew Dunham,Ian Dunham,Richard Durbin,Lisa French,Darren Grafham,Simon G. Gregory,Tim Hubbard,Sean Humphray,Adrienne Hunt,Matthew C. Jones,Christine Lloyd,Amanda McMurray,Lucy Matthews,Simon Mercer,Sarah Milne,James C. Mullikin,Andrew J. Mungall,Robert W. Plumb,Mark T. Ross,Ratna Shownkeen,Sarah Sims,Robert H. Waterston,Richard K. Wilson,LaDeana W. Hillier,John Douglas Mcpherson,Marco A. Marra,Elaine R. Mardis,Lucinda Fulton,Asif T. Chinwalla,Kymberlie H. Pepin,Warren Gish,Stephanie L. Chissoe,Michael C. Wendl,Kim D. Delehaunty,Tracie L. Miner,Andrew Delehaunty,Jason B. Kramer,Lisa Cook,Robert S. Fulton,Douglas L. Johnson,Patrick Minx,Sandra W. Clifton,Trevor Hawkins,Elbert Branscomb,Paul Predki,Paul G. Richardson,Sarah Wenning,Tom Slezak,Norman A. Doggett,Jan Fang Cheng,Anne S. Olsen,Susan Lucas,Christopher J. Elkin,Edward Uberbacher,Marvin Frazier,Richard A. Gibbs,Donna M. Muzny,Steven E. Scherer,John Bouck,Erica Sodergren,Kim C. Worley,Catherine M. Rives,James H. Gorrell,Michael L. Metzker,Susan L. Naylor,Raju Kucherlapati,David L. Nelson,George M. Weinstock,Yoshiyuki Sakaki,Asao Fujiyama,Masahira Hattori,Tetsushi Yada,Atsushi Toyoda,Takehiko Itoh,Chiharu Kawagoe,Hidemi Watanabe,Yasushi Totoki,Todd D. Taylor,Jean Weissenbach,Roland Heilig,William Saurin,François Artiguenave,Philippe Brottier,Thomas Brüls,Eric Pelletier,Catherine Robert,Patrick Wincker,André Rosenthal,Matthias Platzer,Gerald Nyakatura,Stefan Taudien,Andreas Rump,Douglas R. Smith,Lynn Doucette-Stamm,Marc Rubenfield,Keith Weinstock,Mei Lee Hong,Joann Dubois,Huanming Yang,Jun Yu,Jian Wang,Guyang Huang,Jun Gu,Leroy Hood,Lee Rowen,Anup Madan,Shizen Qin,Ronald W. Davis,Nancy A. Federspiel,A. Pia Abola,Michael Proctor,Bruce A. Roe,Feng Chen,Huaqin Pan,Juliane Ramser,Hans Lehrach,Richard Reinhardt,W. Richard McCombie,Melissa De La Bastide,Neilay Dedhia,H. Blöcker,K. Hornischer,Gabriele Nordsiek,Richa Agarwala,L. Aravind,Jeffrey A. Bailey,Alex Bateman,Serafim Batzoglou,Ewan Birney,Peer Bork,Daniel G. Brown,Christopher B. Burge,Lorenzo Cerutti,Lorenzo Cerutti,Hsiu Chuan Chen,Deanna M. Church,Michele E. Clamp,Richard R. Copley,Tobias Doerks,Sean R. Eddy,Evan E. Eichler,Terrence S. Furey,James E. Galagan,James G. R. Gilbert,Cyrus L. Harmon,Yoshihide Hayashizaki,David Haussler,Henning Hermjakob,Karsten Hokamp,Wonhee Jang,L. Steven Johnson,Thomas A. Jones,Simon Kasif,Arek Kaspryzk,Scot Kennedy,W. James Kent,Paul Kitts,Eugene V. Koonin,Ian F Korf,David Kulp,Doron Lancet,Todd M. Lowe,Aoife McLysaght,Tarjei S. Mikkelsen,John V. Moran,Nicola Mulder,Victor J. Pollara,Chris P. Ponting,Greg Schuler,Jörg Schultz,Guy Slater,Arian F.A. Smit,Elia Stupka,Joseph Szustakowki,Danielle Thierry-Mieg,Jean Thierry-Mieg,Lukas Wagner,John W. Wallis,Raymond Wheeler,Alan Williams,Yuri I. Wolf,Kenneth H. Wolfe,Shiaw Pyng Yang,Ru Fang Yeh,Francis S. Collins,Mark S. Guyer,Jane Peterson,Adam Felsenfeld,Kris A. Wetterstrand,Richard M. Myers,Jeremy Schmutz,Mark Dickson,Jane Grimwood,David R. Cox,Maynard V. Olson,Rajinder Kaul,Christopher K. Raymond,Nobuyoshi Shimizu,Kazuhiko Kawasaki,Shinsei Minoshima,Glen A. Evans,Maria Athanasiou,Roger A. Schultz,Aristides Patrinos,Michael J. Morgan,Pieter J. de Jong,Pieter J. de Jong,Joseph J. Catanese,Joseph J. Catanese,Kazutoyo Osoegawa,Kazutoyo Osoegawa,Hiroaki Shizuya,Sangdun Choi,Yu Juin Chen +258 more
Journal ArticleDOI
Novel loci and pathways significantly associated with longevity
Yi Zeng,Yi Zeng,Chao Nie,Junxia Min,Xiaomin Liu,Mengmeng Li,Huashuai Chen,Huashuai Chen,Hanshi Xu,Mingbang Wang,Ting Ni,Yang Li,Han Yan,Jin Pei Zhang,Chun Song,Li Qing Chi,Han Ming Wang,Jie Dong,Gu Yan Zheng,Li Lin,Feng Qian,Yanwei Qi,Xiao Liu,Hongzhi Cao,Yinghao Wang,Lijuan Zhang,Zhaochun Li,Yufeng Zhou,Yan Wang,Jiehua Lu,Jianxin Li,Ming Qi,Lars Bolund,Anatoliy I. Yashin,Kenneth C. Land,Simon G. Gregory,Ze Yang,William K. Gottschalk,Wei Tao,Jian Wang,Jun Wang,Xun Xu,Harold Bae,Marianne Nygaard,Lene Christiansen,Kaare Christensen,Claudio Franceschi,Michael W. Lutz,Jun Gu,Qihua Tan,Thomas T. Perls,Paola Sebastiani,Joris Deelen,Eline Slagboom,Elizabeth R. Hauser,Huji Xu,Xiao-Li Tian,Huanming Yang,James W. Vaupel +58 more
TL;DR: A genome-wide association study of Han Chinese with a sample size 2.7 times the largest previously published GWAS on centenarians suggests protective mechanisms including immunity and nutrient metabolism and their interactions with environmental stress play key roles in human longevity.