S
Simon G. Gregory
Researcher at Duke University
Publications - 216
Citations - 50384
Simon G. Gregory is an academic researcher from Duke University. The author has contributed to research in topics: Single-nucleotide polymorphism & Gene. The author has an hindex of 54, co-authored 198 publications receiving 47130 citations. Previous affiliations of Simon G. Gregory include University of Helsinki & Wellcome Trust.
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Journal ArticleDOI
A candidate gene for congenital bilateral isolated ptosis identified by molecular analysis of a de novo balanced translocation
Tristan F. W. Mcmullan,John A. Crolla,Simon G. Gregory,Nigel P. Carter,Rachel A. Cooper,Gareth R. Howell,David O. Robinson +6 more
TL;DR: The analysis of the chromosome breakpoints in a patient with congenital bilateral isolated ptosis and a de novo balanced translocation 46,XY,t(1;8)(p34.3;q21.12) is described, which shows that Human ZFH-4 is a candidate gene for congenitals bilateral isolated Ptosis and disrupts a gene homologous to the mouse zfh-4 gene.
Journal ArticleDOI
Skewing of the population balance of lymphoid and myeloid cells by secreted and intracellular osteopontin
Masashi Kanayama,Shengjie Xu,Keiko Danzaki,Jason Gibson,Makoto Inoue,Simon G. Gregory,Mari L. Shinohara +6 more
TL;DR: It is found that osteopontin skewed this balance during pathogenic conditions such as infection and autoimmunity, and two isoforms of OPN exerted distinct effects in shifting this balance through cell-type-specific regulation of apoptosis.
Journal ArticleDOI
The physical maps for sequencing human chromosomes 1, 6, 9, 10, 13, 20 and X.
David R. Bentley,Panagiotis Deloukas,Andrew Dunham,Lisa French,Simon G. Gregory,Sean Humphray,Andrew J. Mungall,Mark T. Ross,Nigel P. Carter,Ian Dunham,Carol Scott,K. J. Ashcroft,A. L. Atkinson,K. Aubin,David Beare,Graeme Bethel,N. Brady,J. C. Brook,D. C. Burford,W. D. Burrill,C. Burrows,Adam Butler,C. Carder,J. J. Catanese,C M Clee,S. M. Clegg,V. Cobley,A. J. Coffey,Charlotte G. Cole,John E. Collins,J. S. Conquer,R. A. Cooper,K. M. Culley,Elisabeth Dawson,F. L. Dearden,Richard Durbin,P. J. De Jong,P. D. Dhami,M. E. Earthrowl,Carol A. Edwards,R Evans,Christopher J. Gillson,J. Ghori,L D Green,Rhian Gwilliam,K. S. Halls,S. Hammond,G. L. Harper,R. W. Heathcott,Jane L. Holden,E. Holloway,B. L. Hopkins,P. J. Howard,Gareth R. Howell,E. J. Huckle,Jaime Hughes,P. J. Hunt,Sarah E. Hunt,M. Izmajlowicz,C. A. Jones,Soumi Joseph,G. Laird,Cordelia Langford,M. H. Lehvaslaiho,M.A. Leversha,Owen T. McCann,Louise McDonald,Jennifer McDowall,G. L. Maslen,D. Mistry,Nicholas K. Moschonas,Vassos Neocleous,D. M. Pearson,K. J. Phillips,K. M. Porter,S. R. Prathalingam,Y. H. Ramsey,S. A. Ranby,C. M. Rice,Jane Rogers,L. J. Rogers,Theologia Sarafidou,D. J. Scott,G. J. Sharp,C. J. Shaw-Smith,Luc J. Smink,Carol Soderlund,E. C. Sotheran,Helen E. Steingruber,John Sulston,A. Taylor,Rohan Taylor,A. A. Thorpe,E. J. Tinsley,Georgina Warry,Adam Whittaker,Pamela Whittaker,S. H. Williams,T. E. Wilmer,Richard Wooster,C. L. Wright +100 more
TL;DR: By measuring the remaining gaps, this work can assess chromosome length and coverage in sequenced clones and establish the long-range organization of the maps early in the project.
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Urinary fumonisin B1 and estimated fumonisin intake in women from high- and low-exposure communities in Guatemala.
Olga Torres,Jorge Matute,Janee Gelineau-van Waes,Joyce R. Maddox,Simon G. Gregory,Allison E. Ashley-Koch,Jency L. Showker,Nicholas C. Zitomer,Kenneth A. Voss,Ronald T. Riley +9 more
TL;DR: The FB intake paralleled U FB1 in a dose-dependent manner but UFB1 was present in much higher levels than UFB2 or UFB3 compared to maize, indicating that FB1 is either absorbed better or preferentially excreted in urine.
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The human gene for mannan-binding lectin-associated serine protease-2 (MASP-2), the effector component of the lectin route of complement activation, is part of a tightly linked gene cluster on chromosome 1p36.2-3.
Cordula M. Stover,Yuichi Endo,Minoru Takahashi,Nicholas J. Lynch,Cris S. Constantinescu,Thomas Vorup-Jensen,Steffen Thiel,H Friedl,T Hankeln,R Hall,Simon G. Gregory,Teizo Fujita,Wilhelm J. Schwaeble +12 more
TL;DR: It is shown that the MASP2 gene encodes two gene products, the 76 kDa MASP-2 serine protease and a plasma protein of 19 kDa, termed MAp19 or sMAP, which are components of the lectin pathway activation complex.