S
Simon G. Gregory
Researcher at Duke University
Publications - 216
Citations - 50384
Simon G. Gregory is an academic researcher from Duke University. The author has contributed to research in topics: Single-nucleotide polymorphism & Gene. The author has an hindex of 54, co-authored 198 publications receiving 47130 citations. Previous affiliations of Simon G. Gregory include University of Helsinki & Wellcome Trust.
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An EBV-associated atypical B cell signature in clinically isolated syndrome is implicated in progression of multiple sclerosis
Elliott D. SoRelle,E. Haukenfrers,Vanita Jain,Karen Abramson,E. Hocke,Laura A. Cooney,Kevin M. Harris,Scott S. Zamvil,Simon G. Gregory,M. Luftig +9 more
TL;DR: In this article , the authors report single-cell gene and surface protein expression (scRNA/CITE-seq) in peripheral B cells collected longitudinally from patients with Clinically Isolated Syndrome (CIS) during the Immune Tolerance Network STAyCIS Trial.
Journal Article
Abstract 4108: Identification of Kalirin Gene as a Novel Coronary Artery Disease Gene through Peak-Wide Association Mapping on Chromosome 3q13-21
Liyong Wang,Elizabeth R. Hauser,Svati H. Shah,Carol Haynes,Jason M Rose,Marco Harris,Julie Rombaut,Sarah C. Nelson,A B Hale,David R. Crosslin,Simon G. Gregory,Christopher B. Granger,Jonathan L. Haines,Chris Jones,David C. Crossman,William E. Kraus,Margaret A. Pericak-Vance,Pascal J. Goldschmidt-Clermont,Jeffery M. Vance +18 more
Journal ArticleDOI
Genomic and phenotypic evidence for prostate cancer osteomimicry in circulating tumor cells from men with metastatic castration resistant prostate cancer (mCRPC) treated with radium-223.
Andrew J. Armstrong,Santosh Gupta,Patrick Healy,Gabor Kemeny,Lauren Beth Leith,Michael R. Zalutsky,Charles E. Spritzer,Catrin Davies,Katie Ware,Jason A. Somarelli,Kris C. Wood,Wayne Glover,Shiaowen David Hsu,Drew G. Gerber,Colin Rothwell,Kelly Mundy,Monika Anand,Simon G. Gregory,Susan Halabi,Daniel J. George +19 more
TL;DR: It is hypothesized that PC osteomimicry, a form of epithelial plasticity leading to an osteoblastic phenotype, may contribute to the intralesional deposition of radium-223 and subsequent irradiation of the tumor microenvironment.
Journal ArticleDOI
Abstract 646: Liquid biopsy transcriptomics identify pathways associated with poor outcomes and immune phenotypes in men with mCRPC
Jiaren Zhang,Bob Zimmermann,Giuseppe Galletti,Susan Halabi,Ada Gjyrezi,Qian Yang,Santosh Gupta,Akanksha Verma,Andrea Sboner,Monika Anand,Daniel J. George,Simon G. Gregory,Prerna Mahtani,Seung-Doo Hong,Virginia Pascual,Clio P. Mavragani,Emmanuel S. Antonarakis,David M. Nanus,Scott T. Tagawa,Olivier Elemento,Andrew J. Armstrong,Paraskevi Giannakakou +21 more
TL;DR: It is demonstrated that liquid biopsy transcriptomics of both tumor cells and immune cells can identify molecular pathways associated with treatment resistance paving the way for treatment optimization and the development of novel precision therapies in patients with mCRPC.
Journal Article
Abstract 9035: Epigenetic Modifications are Associated with Ascending Thoracic Aneurysm Formation in Patients with Bicuspid Aortic Valve
Asad A. Shah,Sheng Feng,Deidre R. Krupp,Carol Haynes,Elizabeth Grass,Shu S. Lin,Elizabeth R. Hauser,William E. Kraus,Simon G. Gregory,Svati H. Shah,G. Chad Hughes +10 more
TL;DR: This data indicates that Bicuspid aortic valve disease predisposes to early and more frequent ascending thoracic aortIC aneurysm formation, but the mechanisms underlying this aortopathy remain incompletely...