S
Simon G. Gregory
Researcher at Duke University
Publications - 216
Citations - 50384
Simon G. Gregory is an academic researcher from Duke University. The author has contributed to research in topics: Single-nucleotide polymorphism & Gene. The author has an hindex of 54, co-authored 198 publications receiving 47130 citations. Previous affiliations of Simon G. Gregory include University of Helsinki & Wellcome Trust.
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Journal ArticleDOI
Single-cell genome-wide association reveals that a nonsynonymous variant in ERAP1 confers increased susceptibility to influenza virus
Benjamin Schott,Liuyang Wang,Xinyu Zhu,Alfred T. Harding,Emily R Ko,Jeffrey S. Bourgeois,Erica J. Washington,Thomas W. Burke,Jack G. Anderson,Emma Bergstrom,Zoe Gardener,Suzanna Paterson,Richard G. Brennan,Christopher Chiu,Micah T. McClain,Christopher W. Woods,Simon G. Gregory,Nicholas S. Heaton,Dennis C. Ko +18 more
TL;DR: In this paper , a single-cell high-throughput human in vitro susceptibility testing (scHi-HOST) method was developed for rapidly identifying genetic variants that confer resistance and susceptibility.
Posted ContentDOI
Liquid-biopsy transcriptomic profiling uncovers molecular mediators of resistance to androgen receptor signaling inhibition in lethal prostate cancer
Jiaren Zhang,Zimmermann B,Giuseppe Galletti,Susan Halabi,Ada Gjyrezi,Qian Yang,Santosh Gupta,Akanksha Verma,Andrea Sboner,Monika Anand,Daniel J. George,Simon G. Gregory,S. Hong,S. Hong,Pascual,Mavragani Cp,Emmanuel S. Antonarakis,David M. Nanus,Scott T. Tagawa,Olivier Elemento,Andrew J. Armstrong,Paraskevi Giannakakou +21 more
TL;DR: In this paper, the authors performed transcriptome analysis of circulating tumor cells (CTCs) and peripheral blood mononuclear cells (PBMC) in the context of a prospective clinical trial of men with metastatic castration-resistant prostate cancer (mCRPC) treated with abiraterone (Abi) or enzalutamide (Enza).
Posted ContentDOI
Evaluating DNA methylation age on the Illumina’s methylationEPIC BeadChip
Radhika Dhingra,Lydia Coulter Kwee,David Diaz-Sanchez,Robert B. Devlin,Wayne E. Cascio,Elizabeth R. Hauser,Simon G. Gregory,Svati H. Shah,William E. Kraus,Kenneth Olden,Cavin K. Ward-Caviness +10 more
TL;DR: Correlations between age and DNAm age were not dependent on missing probes or on array designs and consequently associations between DNAmAge and outcomes such as sex remained the same independent of missing probes and probe design.
Journal ArticleDOI
Genetic predisposition of behavioral response
TL;DR: The signaling pathways of neuropeptides oxytocin (OT) and arginine-vasopressin (AVP) are investigated to identify DNA polymorphisms that might explain interindividual differences in response to social cues.
Journal ArticleDOI
Gene-nutrient interactions that impact magnesium homeostasis increase risk for neural tube defects in mice exposed to dolutegravir
Janee Gelineau-van Waes,Michael Van Waes,Jodi Hallgren,Jason Hulen,M. W. Bredehoeft,Allison E. Ashley-Koch,Deidre R. Krupp,Simon G. Gregory,Holly A.F. Stessman +8 more
TL;DR: In this paper , the authors found that mice with pre-existing hypomagnesemia due to genetic variation and/or dietary Mg2+ insufficiency at the time of conception and initiation of DTG treatment would be at increased risk for NTDs.