S
Simon G. Gregory
Researcher at Duke University
Publications - 216
Citations - 50384
Simon G. Gregory is an academic researcher from Duke University. The author has contributed to research in topics: Single-nucleotide polymorphism & Gene. The author has an hindex of 54, co-authored 198 publications receiving 47130 citations. Previous affiliations of Simon G. Gregory include University of Helsinki & Wellcome Trust.
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Journal ArticleDOI
The PROPHECY trial: Multicenter prospective trial of circulating tumor cell (CTC) AR-V7 detection in men with mCRPC receiving abiraterone (A) or enzalutamide (E).
Andrew J. Armstrong,Susan Halabi,Jun Luo,David M. Nanus,Paraskevi Giannakakou,Russell Z. Szmulewitz,Daniel C. Danila,Patrick Healy,Monika Anand,Colin Rothwell,John L. Silberstein,Giuseppe Galletti,Jason A. Somarelli,Santosh Gupta,Simon G. Gregory,Howard I. Scher,Ryan Dittamore,Scott T. Tagawa,Emmanuel S. Antonarakis,Daniel J. George +19 more
TL;DR: It is unclear if CTC AR-V7 detection is a valid predictive biomarker of clinical efficacy in men with mCRPC receiving A/E or just an indicator of aggressive disease and high tumor b...
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Joint eQTL assessment of whole blood and dura mater tissue from individuals with Chiari type I malformation
Eric F. Lock,Karen Soldano,Melanie E. Garrett,Heidi Cope,Christina A. Markunas,Herbert E. Fuchs,Gerald A. Grant,Gerald A. Grant,David B. Dunson,Simon G. Gregory,Allison E. Ashley-Koch +10 more
TL;DR: Despite strong overall heterogeneity in expression levels between blood and dura, the majority of cis-eQTLs are shared by both tissues, providing new insight into the genetic basis for Chiari Type I Malformation and related conditions.
Journal ArticleDOI
Gene-smoking interactions in multiple Rho-GTPase pathway genes in an early-onset coronary artery disease cohort.
Cavin K. Ward-Caviness,Carol Haynes,Colette Blach,Elaine Dowdy,Simon G. Gregory,Svati H. Shah,Benjamin D. Horne,William E. Kraus,Elizabeth R. Hauser,Elizabeth R. Hauser +9 more
TL;DR: A pathway-based analysis of the association results using WebGestalt revealed several enriched pathways including the regulation of the actin cytoskeleton pathway as defined by the Kyoto Encyclopedia of Genes and Genomes.
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Circulating MicroRNA Profiling in Non-ST Elevated Coronary Artery Syndrome Highlights Genomic Associations with Serial Platelet Reactivity Measurements.
Kristian C. Becker,Lydia Coulter Kwee,Megan L. Neely,Elizabeth Grass,Joseph A. Jakubowski,Keith A.A. Fox,Harvey D. White,Simon G. Gregory,Paul A. Gurbel,Leonardo de Pinto Carvalho,Richard C. Becker,E. Magnus Ohman,E. Magnus Ohman,Matthew T. Roe,Matthew T. Roe,Svati H. Shah,Svati H. Shah,Mark Y. Chan +17 more
TL;DR: Three significant microRNAs were consistently associated with PR in the TRILOGY-ACS and independent Singapore post- ACS cohorts, suggesting the measurement of circulating microRNA concentrations may report on dynamic changes in platelet biology following a cardiovascular ischemic event.
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Single-Cell RNA Sequencing Reveals Cellular and Transcriptional Changes Associated With M1 Macrophage Polarization in Hidradenitis Suppurativa.
Paula Mariottoni,Simon W. Jiang,Courtney A. Prestwood,Vaibhav Jain,Jutamas Suwanpradid,Melodi Javid Whitley,Margaret Coates,David Brown,Detlev Erdmann,David L. Corcoran,Simon G. Gregory,Tarannum Jaleel,Jennifer Y. Zhang,Tamia A. Harris-Tryon,Amanda S. MacLeod +14 more
TL;DR: In this article, a shared upregulation of genes involved in interferon (IFN) and antimicrobial defense signaling through transcriptomic overlap analysis of differentially expressed genes (DEGs) in datasets from Hidradenitis suppurativa (HS) skin, diabetic foot ulcers (DFUs), and the inflammatory stage of normal healing wounds was identified.