S
Sivan Osenberg
Researcher at Sheba Medical Center
Publications - 8
Citations - 3466
Sivan Osenberg is an academic researcher from Sheba Medical Center. The author has contributed to research in topics: RNA editing & RNA. The author has an hindex of 6, co-authored 6 publications receiving 2412 citations. Previous affiliations of Sivan Osenberg include Tel Aviv University.
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Journal ArticleDOI
Topology of the human and mouse m6A RNA methylomes revealed by m6A-seq
Dan Dominissini,Sharon Moshitch-Moshkovitz,Schraga Schwartz,Schraga Schwartz,Mali Salmon-Divon,Lior Ungar,Sivan Osenberg,Sivan Osenberg,Karen Cesarkas,Jasmine Jacob-Hirsch,Ninette Amariglio,Martin Kupiec,Rotem Sorek,Gideon Rechavi,Gideon Rechavi +14 more
TL;DR: The findings suggest that RNA decoration by m6A has a fundamental role in regulation of gene expression, and a subset of stimulus-dependent, dynamically modulated sites is identified.
Journal ArticleDOI
Alu Sequences in Undifferentiated Human Embryonic Stem Cells Display High Levels of A-to-I RNA Editing
Sivan Osenberg,Sivan Osenberg,Nurit Paz Yaacov,Nurit Paz Yaacov,Michal Safran,Sharon Moshkovitz,Ronit Shtrichman,Ofra Sherf,Jasmine Jacob-Hirsch,Gilmor Keshet,Ninette Amariglio,Joseph Itskovitz-Eldor,Joseph Itskovitz-Eldor,Gideon Rechavi,Gideon Rechavi +14 more
TL;DR: It is speculated that A-to-I editing of Alu sequences plays a role in the regulation of hESC early differentiation decisions, including neurogenesis.
Journal ArticleDOI
Altered A-to-I RNA Editing in Human Embryogenesis
Ronit Shtrichman,Igal Germanguz,Rachel Mandel,Anna Ziskind,Irit Nahor,Michal Safran,Sivan Osenberg,Ofra Sherf,Gideon Rechavi,Joseph Itskovitz-Eldor +9 more
TL;DR: The data suggest that A-to-I RNA editing plays a critical role during early human development, and suggests that ADAR1 protein is substantially regulated in undifferentiated pluripotent hESCs.
Journal ArticleDOI
Widespread cleavage of A-to-I hyperediting substrates.
TL;DR: Bioinformatics analysis of publicly available mRNA and expressed sequence tag data provides evidence showing that neighboring, reversely oriented, Alu elements are often cleaved at both ends of the region harboring the inverted repeats followed by rejoining of the two parts of the transcript on both sides of the inverted repeat, resulting in almost inosine-free mRNA products.
Journal ArticleDOI
Consistent levels of A-to-I RNA editing across individuals in coding sequences and non-conserved Alu repeats
Shoshana Greenberger,Shoshana Greenberger,Erez Y. Levanon,Nurit Paz-Yaacov,Aviv Barzilai,Michal Safran,Sivan Osenberg,Ninette Amariglio,Gideon Rechavi,Eli Eisenberg +9 more
TL;DR: The findings suggest that A-to-I RNA-editing of Alu elements is a tightly regulated process and, as such, might have been recruited in the course of primate evolution for post-transcriptional regulatory mechanisms.