D
Dan Dominissini
Researcher at Tel Aviv University
Publications - 34
Citations - 4518
Dan Dominissini is an academic researcher from Tel Aviv University. The author has contributed to research in topics: Medicine & Internal medicine. The author has an hindex of 15, co-authored 25 publications receiving 3176 citations. Previous affiliations of Dan Dominissini include University of Chicago & Howard Hughes Medical Institute.
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Journal ArticleDOI
Gene expression regulation mediated through reversible m 6 A RNA methylation
TL;DR: This Review focuses on reversible methylation through the most prevalent mammalian mRNA internal modification, N6-methyladenosine (m6A), and indicates dynamic regulatory roles that are analogous to the well-known reversible epigenetic modifications of DNA and histone proteins.
Journal ArticleDOI
m6A mRNA methylation facilitates resolution of naïve pluripotency toward differentiation
Shay Geula,Sharon Moshitch-Moshkovitz,Dan Dominissini,Abed AlFatah Mansour,Nitzan Kol,Mali Salmon-Divon,Vera Hershkovitz,Eyal Peer,Nofar Mor,Yair S. Manor,Moshe Shay Ben-Haim,Eran Eyal,Sharon Yunger,Yishay Pinto,Diego Jaitin,Sergey Viukov,Yoach Rais,Vladislav Krupalnik,Elad Chomsky,Mirie Zerbib,Itay Maza,Yoav Rechavi,Rada Massarwa,Suhair Hanna,Suhair Hanna,Ido Amit,Erez Y. Levanon,Ninette Amariglio,Ninette Amariglio,Noam Stern-Ginossar,Noa Novershtern,Gideon Rechavi,Jacob H. Hanna +32 more
TL;DR: It is shown that N6-methyladenosine (m6A), a messenger RNA (mRNA) modification present on transcripts of pluripotency factors, drives this transition from the pluripotent to the differentiated state.
Journal ArticleDOI
The dynamic N 1 -methyladenosine methylome in eukaryotic messenger RNA
Dan Dominissini,Dan Dominissini,Sigrid Nachtergaele,Sigrid Nachtergaele,Sharon Moshitch-Moshkovitz,Eyal Peer,Eyal Peer,Nitzan Kol,Moshe Shay Ben-Haim,Moshe Shay Ben-Haim,Qing Dai,Qing Dai,Ayelet Di Segni,Mali Salmon-Divon,Wesley C. Clark,Guanqun Zheng,Tao Pan,Oz Solomon,Oz Solomon,Eran Eyal,Vera Hershkovitz,Dali Han,Dali Han,Louis C. Dore,Louis C. Dore,Ninette Amariglio,Ninette Amariglio,Gideon Rechavi,Gideon Rechavi,Chuan He,Chuan He +30 more
TL;DR: It is shown that m1A is enriched around the start codon upstream of the first splice site: it preferentially decorates more structured regions around canonical and alternative translation initiation sites, is dynamic in response to physiological conditions, and correlates positively with protein production.
Journal ArticleDOI
High-resolution N(6) -methyladenosine (m(6) A) map using photo-crosslinking-assisted m(6) A sequencing.
Kai Chen,Zhike Lu,Xiao Wang,Ye Fu,Guan-Zheng Luo,Nian Liu,Dali Han,Dan Dominissini,Qing Dai,Tao Pan,Chuan He +10 more
TL;DR: A photo-crosslinking-assisted m(6) A sequencing strategy is presented to more accurately define sites with m( 6) A modification and provides insight into the relationship between the methylation regions and the binding sites of RNA-binding proteins.
Journal ArticleDOI
Nm-seq maps 2′- O -methylation sites in human mRNA with base precision
Qing Dai,Sharon Moshitch-Moshkovitz,Dali Han,Dali Han,Nitzan Kol,Ninette Amariglio,Ninette Amariglio,Gideon Rechavi,Gideon Rechavi,Dan Dominissini,Dan Dominissini,Chuan He +11 more
TL;DR: Nm-seq uncovered thousands of Nm sites in human mRNA with features suggesting functional roles, and leveraged the differential reactivity of 2′-O-methylated and2′-hydroxylated nucleosides to periodate oxidation to develop Nm- sequencing, a sensitive method for transcriptome-wide mapping of Nn with base precision.