Sivan Osenberg

TL;DR: The findings suggest that RNA decoration by m6A has a fundamental role in regulation of gene expression, and a subset of stimulus-dependent, dynamically modulated sites is identified.

TL;DR: It is speculated that A-to-I editing of Alu sequences plays a role in the regulation of hESC early differentiation decisions, including neurogenesis.

TL;DR: The data suggest that A-to-I RNA editing plays a critical role during early human development, and suggests that ADAR1 protein is substantially regulated in undifferentiated pluripotent hESCs.

TL;DR: Bioinformatics analysis of publicly available mRNA and expressed sequence tag data provides evidence showing that neighboring, reversely oriented, Alu elements are often cleaved at both ends of the region harboring the inverted repeats followed by rejoining of the two parts of the transcript on both sides of the inverted repeat, resulting in almost inosine-free mRNA products.

TL;DR: The findings suggest that A-to-I RNA-editing of Alu elements is a tightly regulated process and, as such, might have been recruited in the course of primate evolution for post-transcriptional regulatory mechanisms.